近期,沈陽(yáng)藥科大學(xué)孫進(jìn)教授團(tuán)隊(duì)、羅聰教授團(tuán)隊(duì)與新加坡國(guó)立大學(xué)陳小元教授團(tuán)隊(duì)共同合作在美國(guó)化學(xué)會(huì)旗下期刊《ACS nano》(IF=17.1)上發(fā)表題為“Self-Adjuvanting Polyguanidine Nanovaccines for Cancer Immunotherapy”(用于癌癥免疫治療的自我輔助聚胍納米疫苗)的研究。在這項(xiàng)工作中,研究團(tuán)隊(duì)通過(guò)不同的胍基基序修飾支鏈聚乙烯亞胺(PEI)來(lái)設(shè)計(jì)聚胍(PolyGu)自佐劑納米疫苗載體,并使用蛋白和mRNA抗原制備納米疫苗以探索其免疫活性。使用卵清蛋白(OVA)作為模型抗原,通過(guò)簡(jiǎn)單的混合過(guò)程制備納米疫苗,并研究了它們對(duì)腫瘤免疫治療的體外和體內(nèi)影響。結(jié)果表明,胍修飾顯著增強(qiáng)了PEI的安全性,有效激活樹(shù)突狀細(xì)胞(DC)并促進(jìn)其成熟。此外,研究團(tuán)隊(duì)進(jìn)一步探索了多胍材料作為 mRNA 疫苗載體的潛力,也取得了良好的反饋。
圖1;構(gòu)建多胍腫瘤納米疫苗平臺(tái),整合佐劑于疫苗遞送載體。
在該項(xiàng)研究中,使用了欣博盛生物(NeoBioscience Technology Co, Ltd)的QuantiCyto? Mouse IL-1β, Mouse IL-6 and Mouse IL-12p70 ELISA kits,用于相關(guān)細(xì)胞因子含量的測(cè)定。
貨號(hào) | 產(chǎn)品名稱 | 靈敏度 | 檢測(cè)范圍 |
7.8pg/ml | 15.6-1000pg/ml | ||
7.8pg/ml | 15.6-1000pg/ml | ||
7.8pg/ml | 15.6-1000pg/ml |
欣博盛生物非常榮幸能夠作為供應(yīng)商為該項(xiàng)研究提供高品質(zhì)ELISA試劑盒,為生物醫(yī)學(xué)領(lǐng)域的科研探索貢獻(xiàn)一份力量。
2024年2月文獻(xiàn)引用
1. Self-Adjuvanting Polyguanidine Nanovaccines for Cancer Immunotherapy(ACS nano,IF=17.1)
發(fā)表時(shí)間:26/02/2024
作者:Zhang X, Wang K, Zhao Z, et al.
作者單位:沈陽(yáng)藥科大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6 and IL-12p70 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38407021/
2. Multifunctional Injectable Microspheres Containing “Naturally-Derived” Photothermal Transducer for Synergistic Physical and Chemical Treating of Acute Osteomyelitis through Sequential Immunomodulation(ACS nano,IF=17.1)
發(fā)表時(shí)間:09/02/2024
作者:Shen Y, Xu Y, Yu Z, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Rat TNF-α and IL-6 ELISA kits;normal goat serum
https://pubmed.ncbi.nlm.nih.gov/38335113/
3. Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma(Nature Communications,IF=16.6)
發(fā)表時(shí)間:26/02/2024
作者:He M, Liu Y, Chen S, et al.
作者單位:中山大學(xué)
使用產(chǎn)品:Human Albumin ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38409200/
4. Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis(International Journal of Oral Science,IF=14.9)
發(fā)表時(shí)間:26/02/2024
作者:Yang X, Zhao H, Li R, et al.
作者單位:華中科技大學(xué)
使用產(chǎn)品:Human TGF-β1 ELISA
https://pubmed.ncbi.nlm.nih.gov/38403794/
5. Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties(Acta Pharmaceutica Sinica B,IF=14.5)
發(fā)表時(shí)間:02/02/2024
作者:Hao Y, Wang H, Liu X, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Mouse IL-1β, TNF-α and IL-6 ELISA kits
6. Tumor Homing Chimeric Peptide Rhomboids to Improve Photodynamic Performance by Inhibiting Therapy‐Upregulated Cyclooxygenase‐2(Small,IF=13.3)
發(fā)表時(shí)間:11/02/2024
作者:Zhang W, Yu B X, Chen X Y, et al.
作者單位:廣東藥科大學(xué)
使用產(chǎn)品:Mouse IL-6, TNF-α and IL-12p70 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38342670/
7. A facile Immunoregulatory Constructional Design by Proanthocyanidin Optimizing Directional Chitosan Microchannel(Small,IF=13.3)
發(fā)表時(shí)間:29/02/2024
作者:Li X, Wang Y, Zhao C, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β, TGF-β1, and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38421135/
8. Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer(Journal of Controlled Release,IF=10.8)
發(fā)表時(shí)間:08/02/2024
作者:Gong X, Zheng C, Cai Y, et al.
作者單位:中國(guó)醫(yī)藥工業(yè)研究總院
使用產(chǎn)品:Mouse IL-12p40, TNF-α, IFN-γ, MCP-1 and VEGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38295994/
9. Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer - PubMed (nih.gov)(Advanced Healthcare Materials,IF=10)
發(fā)表時(shí)間:07/02/2024
作者:Zhang Q, Liu Z, Li B, et al.
作者單位:上海交通大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-1β, TNF-α, TGF-β1 and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38295994/
10. Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma(Cell Death & Disease,IF=9)
發(fā)表時(shí)間:26/02/2024
作者:Tan Y Q, Sun B, Zhang X, et al.
作者單位:清華大學(xué)深圳研究生院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/38409090/
11. TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli(Cell Communication and Signaling,IF=8.4)
發(fā)表時(shí)間:15/02/2024
作者:Sun J, Yang R, Fu J, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-6 and MIP-2 ELISA kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38360663/
12. The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds(Cellular & Molecular Biology Letters,IF=8.3)
發(fā)表時(shí)間:05/02/2024
作者:Li C, Xiong Y, Fu Z, et al.
作者單位:昆明醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6, and IL-1β ELISA kits
樣本類型:皮膚組織
https://pubmed.ncbi.nlm.nih.gov/38317065/
13. Autoinducer-2 promotes the colonization of Lactobacillus rhamnosus GG to improve the intestinal barrier function in a neonatal mouse model of antibiotic-induced intestinal dysbiosis(Journal of Translational Medicine,IF=7.4)
發(fā)表時(shí)間:18/02/2024
作者:Hu R, Yang T, Ai Q, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse TNF-α and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38369503/
14. Group 1 innate lymphoid cell activation via recognition of NKG2D and liver resident macrophage MULT-1: Collaborated roles in triptolide induced hepatic immunotoxicity in mice(Ecotoxicology and Environmental Safety,IF=6.8)
發(fā)表時(shí)間:10/02/2024
作者:Zhang H, Tang Q, Miao Y, et al.
作者單位:中國(guó)藥科大學(xué)
使用產(chǎn)品:Mouse IFN-γ, TNF-α and IL-12p70 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38342011/
15. The structure and potential allergenicity of peanut allergen monomers after roasting(Food & Function,IF=6.1)
發(fā)表時(shí)間:14/02/2024
作者:Zhang Y, Geng Q, Song M, et al.
作者單位:南昌大學(xué)
使用產(chǎn)品:Human IL-4, TNF-α ELISA kits and HRP-streptavidin
https://pubmed.ncbi.nlm.nih.gov/38353700/
16. P2X7 receptor of olfactory bulb microglia plays a pathogenic role in stress-related depression in mice with allergic rhinitis(Neurobiology of Disease,IF=6.1)
發(fā)表時(shí)間:06/02/2024
作者:Mou Y, Sun C, Wei S, et al.
作者單位:青島大學(xué)
使用產(chǎn)品:Mouse IL-5 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38331352/
17. Isolation, purification, degradation of citrus pectin and correlation between molecular weight and their biological properties(LWT,IF=6)
發(fā)表時(shí)間:07/02/2024
作者:Guo H, Du Y, Gao H, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Human TNF-α, and IL-6 ELISA kits
https://www.sciencedirect.com/science/article/pii/S0023643824001166
18. Elucidating the mechanisms underlying astrocyte-microglia crosstalk in hippocampal neuroinflammation induced by acute diquat exposure(Environmental Science and Pollution Research,IF=5.8)
發(fā)表時(shí)間:02/02/2024
作者:Qi C, Yan Y, Cao Q, et al.
作者單位:河北醫(yī)科大學(xué)
使用產(chǎn)品:Rat IL-1β and TNF-α ELISA kits
樣本類型:海馬組織
https://pubmed.ncbi.nlm.nih.gov/38305974/
19. FXR controls duodenogastric reflux-induced gastric inflammation through negatively regulating ER stress-associated TNXIP/NLPR3 inflammasome(Iscience,IF=5.8)
發(fā)表時(shí)間:06/02/2024
作者:Yu J, Zhao C, Zhao P, et al.
作者單位:西安交通大學(xué)
使用產(chǎn)品:Human IL-1β ELISA kit, Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38439955/
20. Electroacupuncture at ST36 modulates the intestinal microecology and may help repair the intestinal barrier in the rat model of severe acute pancreatitis(Microbial Biotechnology,IF=5.7)
發(fā)表時(shí)間:21/02/2024
作者:Xu H, Wen Q, Hu H, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Rat TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38381095/
21. Geraniin restricts inflammasome activation and macrophage pyroptosis by preventing the interaction between ASC and NLRP3 to exert anti-inflammatory effects(International Immunopharmacology,IF=5.6)
發(fā)表時(shí)間:09/02/2024
作者:Zhou X, Qin M, He L, et al.
作者單位:廣州中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38340422/
22. Absence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice(CNS Neuroscience & Therapeutics,IF=5.5)
發(fā)表時(shí)間:07/02/2024
作者:Ge Y, Yang J, Chen J, et al.
作者單位:華中科技大學(xué)
使用產(chǎn)品:mouse IL-1β and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38421089/
23. Transcription factor CEBPB mediates intracranial aneurysm rupture by inflammatory and immune response(CNS Neuroscience & Therapeutics,IF=5.5)
發(fā)表時(shí)間:08/02/2024
作者:Tian Z, Wu X, Zhang B, et al.
作者單位:首都醫(yī)科大學(xué)附屬醫(yī)院
使用產(chǎn)品:Human/Mouse IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38332649/
24. Effective substances and molecular mechanisms guided by network pharmacology: An example study of Scrophulariae Radix treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries(Journal of Ethnopharmacology,IF=5.4)
發(fā)表時(shí)間:28/02/2024
作者:Sheng M Y, Peng D W, Peng H M, et al.
作者單位:湖北中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β, and IL-6 ELISA kits
樣本類型:肝臟組織
https://pubmed.ncbi.nlm.nih.gov/38423410/
25. Interleukin-22 Contributes to Blood–Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis(ACS Infectious Diseases,IF=5.3)
發(fā)表時(shí)間:06/02/2024
作者:Yang R, Chen J, Qu X, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse VEGF ELISA kit
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38317607/
26. Peptide OM-LV20 promotes arteriogenesis induced by femoral artery ligature via the miR-29b-3p/VEGFA axis(Atherosclerosis,IF=5.3)
發(fā)表時(shí)間:28/02/2024
作者:Zhang Y, Kang Z, Wang J, et al.
作者單位:昆明醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IFN-β, IL-1β, IL-23, IL-17 and IL-22 ELISA kits
樣本類型:常規(guī)樣本;支氣管灌洗液
https://pubmed.ncbi.nlm.nih.gov/38492245/
27. Intranasal B5 promotes mucosal defence against Actinobacillus pleuropneumoniae via ameliorating early immunosuppression(Virulence,IF=5.2)
發(fā)表時(shí)間:20/02/2024
作者:Huang J, Kang W, Yi D, et al.
作者單位:廣西大學(xué)
使用產(chǎn)品:Mouse TNF-α, IFN-β, IL-1β, IL-23, IL-17 and IL-22 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38378464/
28. The composition of phenolic compounds in Chinese olive (Canarium album L.) cultivars and their contribution to the anti-inflammatory properties of the cultivars(Frontiers in Nutrition,IF=5)
發(fā)表時(shí)間:19/02/2024
作者:He F, Du Y, Pan Z, et al.
作者單位:華南農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38439923/
29. Chensinin-1b Alleviates DSS-Induced Inflammatory Bowel Disease by Inducing Macrophage Switching from the M1 to the M2 Phenotype(Biomedicines,IF=4.7)
發(fā)表時(shí)間:01/02/2024
作者:Sun Y, Li H, Duan X, et al.
作者單位:遼寧師范大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6, IL-10, and TGF-β1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38397947/
30. Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway(Journal of Inflammation Research,IF=4.5)
發(fā)表時(shí)間:26/02/2024
作者:Sun M, Wang F, Li H, et al.
作者單位:華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6, and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38434585/
31. Astragalus polysaccharide improves diabetic ulcers by promoting M2-polarization of macrophages to reduce excessive inflammation via the β-catenin/ NF-κB axis at the late phase of wound-healing(Heliyon,IF=4)
發(fā)表時(shí)間:05/02/2024
作者:Zhen Z, Wei S, Yunfei W, et al.
作者單位:上海中醫(yī)藥大學(xué)附屬龍華醫(yī)院
使用產(chǎn)品:Rat IL-6, IL-1β, IL-10 and TNF-α ELISA kits
樣本類型:常規(guī)樣本;皮膚組織
https://pubmed.ncbi.nlm.nih.gov/38390059/
32. Curcumin protects mice with myasthenia gravis by regulating the gut microbiota, short-chain fatty acids, and the Th17/Treg balance(Heliyon,IF=4)
發(fā)表時(shí)間:15/02/2024
作者:Sun J, Xie Q, Sun M, et al.
作者單位:蘭州大學(xué)第二醫(yī)院
使用產(chǎn)品:Mouse IL-6, IL-10, IL-17A, IL-23 and TGF-β1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38420408/
33. Immunogenicity and protective efficacy of Ag85A and truncation of PstS1 fusion protein vaccines against tuberculosis(Heliyon,IF=4)
發(fā)表時(shí)間:23/02/2024
作者:Zeng L, Ma X, Qu M, et al.
作者單位:中國(guó)農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-2, IL-10, and IL-17 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38463854/
34. Enhanced Cellular Delivery of Tildipirosin by Xanthan Gum–Gelatin Composite Nanogels(Langmuir,IF=3.9)
發(fā)表時(shí)間:23/02/2024
作者:Li X, Liu J, Dou J, et al.
作者單位:安徽科技大學(xué)
使用產(chǎn)品:Mouse IL-6, TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38394629/
35. p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2(Virology,IF=3.7)
發(fā)表時(shí)間:10/02/2024
作者:Liu J, Gao L, Zhou N, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse IL-6, IL-8 and CXCL10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38368639/
36. Let-7b-5p promotes triptolide-induced growth-inhibiting effects in glioma by targeting IGF1R(Naunyn-Schmiedeberg's Archives of Pharmacology,IF=3.6)
發(fā)表時(shí)間:16/02/2024
作者:Liu X, Zhao P, Du X, et al.
作者單位:河南中醫(yī)藥大學(xué)
使用產(chǎn)品:HRP-conjugated secondary antibodies
https://pubmed.ncbi.nlm.nih.gov/38363352/
37. CD5L induces inflammation and survival in RA-FLS through ERK1/2 MAPK pathway(Autoimmunity,IF=3.5)
發(fā)表時(shí)間:29/02/2024
作者:Yang H, Luo Y, Lai X.
作者單位:重慶醫(yī)科大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Human IL-6, IL-8, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38425093/
38. hsa_circ_0008500 regulates Benzo(a)pyrene-loaded gypsum-induced inflammation and apoptosis in human bronchial epithelial cells via activation of Ahr/C-myc pathways(Toxicology Letters,IF=3.5)
發(fā)表時(shí)間:24/02/2024
作者:Wang Y, Song J, He J, et al.
作者單位:川北醫(yī)學(xué)院
使用產(chǎn)品:Human IL-8 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38408587/
39. Response surface optimization of active peptides of Rana spinosa (Quasipaa spinosa) meat process and evaluation of immunomodulatory activity(Journal of Food Measurement and Characterization,IF=3.4)
發(fā)表時(shí)間:07/02/2024
作者:Zeng Y, Cheng H, Shen J, et al.
作者單位:華南農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-6, TNF-α ELISA kits
https://link.springer.com/article/10.1007/s11694-023-02337-1
40. PPM1G regulates hepatic ischemia/reperfusion injury through STING‐mediated inflammatory pathways in macrophages(Immunity, Inflammation and Disease,IF=3.2)
發(fā)表時(shí)間:19/02/2024
作者:Peng D, Huang Z, Yang H, et al.
作者單位:重慶醫(yī)科大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38372470/
41. Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis(Journal of Medicinal Food,IF=2.4)
發(fā)表時(shí)間:15/02/2024
作者:Luo R, Hu Y, Wang L, et al.
作者單位:貴州中醫(yī)藥大學(xué)
使用產(chǎn)品:Human IL-1β and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38294790/
42. New sesquiterpenoids from Biscogniauxia sp.(Journal of Asian Natural Products Research,IF=1.7)
發(fā)表時(shí)間:14/02/2024
作者:Zhang M, Zhao H, Kong J W, et al.
作者單位:暨南大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA kit