近期,中國科學(xué)院上海藥物研究所于海軍老師課題組在國際權(quán)威學(xué)術(shù)期刊Advanced materials上發(fā)表了題為“Engineering Stimuli-Activatable Boolean Logic Prodrug Nanoparticles for Combination Cancer Immunotherapy”的論文,本文首次報(bào)道了一種用于免疫調(diào)節(jié)劑(如免疫激活劑和免疫抑制劑)的腫瘤靶向協(xié)同輸送及聯(lián)合免疫治療的布爾邏輯前藥納米粒(BLPNs)。構(gòu)建了一個(gè)刺激激活BLPNs庫,通過調(diào)整輸入組合包括腫瘤微環(huán)境中的細(xì)胞外基質(zhì)金屬蛋白2/9(MMP-2/9)、細(xì)胞內(nèi)酸度(pH=5.0-6.0)和還原型谷胱甘肽,來產(chǎn)生YES/AND邏輯輸出。通過指定正交刺激-不穩(wěn)定部分的分子結(jié)構(gòu)和連接性,同時(shí)利用腫瘤部位內(nèi)源性信號(hào),實(shí)現(xiàn)對(duì)BLPNs分解和前藥活化的選擇性可調(diào)控制,進(jìn)一步證明了BLPNs在腫瘤中的特異性分布和高效腫瘤免疫治療中免疫調(diào)節(jié)劑的刺激激活作用。本研究結(jié)果為腫瘤藥物特異性輸送和精準(zhǔn)的癌癥免疫治療開辟了新的途徑。
本研究使用欣博盛IL-6, TNF-ɑ和IFN-γ ELISA試劑盒檢測了小鼠腫瘤組織樣本中的細(xì)胞因子的含量。
文章影響因子:25.809
文章鏈接:https://www.ncbi.nlm.nih.gov/pubmed/32048361
以下是2020年4月欣博盛品牌產(chǎn)品SCI文獻(xiàn)引用文章匯總
1.文章題目:Aging-induced IL27Ra Signaling Impairs Hematopoietic Stem Cells.
期 刊:Blood(影響因子:16.562)
發(fā)表時(shí)間:17 April 2020
作 者:He H, Xu P, Zhang X, et al.
作者單位:清華大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA Kit
https://www.ncbi.nlm.nih.gov/pubmed/32305041
2.文章題目:Dipeptide Self-Assembled Hydrogels with Shear-Thinning and Instantaneously Self-Healing Properties Determined by Peptide Sequences.
期 刊:ACS Applied Materials & Interfaces(影響因子:8.456)
發(fā)表時(shí)間:22 April 2020
作 者:Ren P, Li J, Zhao L, et al.
作者單位:中國科學(xué)院過程工程研究所
使用產(chǎn)品:Mouse IL-6, IL-10, TNF-α, TGF-β1 ELISA Kits
樣本類型:皮膚組織
https://www.ncbi.nlm.nih.gov/pubmed/32319760
3.文章題目:Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury.
期 刊:Cell Death & Disease(影響因子:5.959)
發(fā)表時(shí)間:17 April 2020
作 者:Li J, Zhao J, Xu M, et al.
作者單位:上海交通大學(xué)醫(yī)學(xué)院仁濟(jì)醫(yī)院
使用產(chǎn)品:Mouse IL-6, TNF-α and IL-1β ELISA Kits
https://www.ncbi.nlm.nih.gov/pubmed/32303674
4.文章題目:Dual modulation of formyl peptide receptor 2 by aspirin-triggered lipoxin contributes to its anti-inflammatory activity.
期 刊:The FASEB Journal(影響因子:5.391)
發(fā)表時(shí)間:02 April 2020
作 者:Ge Y, Zhang S, Wang J, et al.
作者單位:澳門大學(xué)
使用產(chǎn)品:Human IL-8 ELISA Kit
https://www.ncbi.nlm.nih.gov/pubmed/32239559
5.文章題目:B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells.
期 刊:OncoImmunology(影響因子:5.333)
發(fā)表時(shí)間:14 April 2020
作 者:Lu H, Shi T, Wang M, et al.
作者單位:蘇州大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Human IFN-γ, IL-17/IL-17A, IL-4 and TNF-α ELISA Kits
https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1748991
6.文章題目:Changes in colonic microbiotas in rat after long-term exposure to low dose of okadaic acid.
期 刊:Chemosphere(影響因子:5.108)
發(fā)表時(shí)間:25 April 2020
作 者:Liu Y, Zheng J W, Peng X C, et al.
作者單位:暨南大學(xué)
使用產(chǎn)品:Rat TNF-α, IL-6, IL-8 and IL-10 ELISA Kits
https://www.sciencedirect.com/science/article/pii/S0045653520310675
7.文章題目:Tricarabrols AC, three anti-inflammatory sesquiterpene lactone trimers featuring methylene-tethered linkage from Carpesium faberi.
期 刊:Organic Chemistry Frontiers(影響因子:5.076)
發(fā)表時(shí)間:22 April 2020
作 者:Yuan J, Wen X, Ke C Q, et al.
作者單位:中國科學(xué)院上海藥物研究所
使用產(chǎn)品:Mouse TNF-α, IL-6 and MCP-1 ELISA Kits
https://pubs.rsc.org/en/content/articlelanding/2020/qo/d0qo00093k#!divAbstract
8.文章題目:Combined blockade of TGf-β1 and GM-CSF improves chemotherapeutic effects for pancreatic cancer by modulating tumor microenvironment.
期 刊:Cancer Immunology, Immunotherapy(影響因子:4.9)
發(fā)表時(shí)間:13 April 2020
作 者:Liu Q, Wu H, Li Y, et al.
作者單位:北京協(xié)和醫(yī)學(xué)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://www.ncbi.nlm.nih.gov/pubmed/32285172
9.文章題目:Immunization With a Secreted Esterase Protects Mice Against Multiple Serotypes (M1, M3, and M28) of Group A Streptococcus.
期 刊:Frontiers in Microbiology(影響因子:4.259)
發(fā)表時(shí)間:03 April 2020
作 者:Zhang X, Wei D, Zhao Y, et al.
作者單位:哈爾濱醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IgG ELISA Kit
https://www.frontiersin.org/articles/10.3389/fmicb.2020.00565/full
10.文章題目:Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer.
期 刊:Frontiers in Oncology(影響因子:4.137)
發(fā)表時(shí)間:April 2020
作 者:Shang H, Zhao J, Yao J, et al.
作者單位:山東大學(xué)附屬千佛山醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://www.ncbi.nlm.nih.gov/pubmed/32300552
11.文章題目:Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.
期 刊:Phytotherapy Research(影響因子:3.766)
發(fā)表時(shí)間:17 April 2020
作 者:Min X, Zeng X, Zhao W, et al.
作者單位:遵義醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β and IL-6 ELISA Kits
樣本類型:結(jié)腸組織
https://www.ncbi.nlm.nih.gov/pubmed/32302031
12.文章題目:Probiotic Enterococcus faecalis Symbioflor 1 ameliorates pathobiont-induced miscarriage through bacterial antagonism and Th1-Th2 modulation in pregnant mice.
期 刊:Applied Microbiology and Biotechnology(影響因子:3.67)
發(fā)表時(shí)間:20 April 2020
作 者:Tao Y, Huang F, Zhang Z, et al.
作者單位:南昌大學(xué)
使用產(chǎn)品:Mouse TNF-α, IFN-α and IL-10 ELISA Kits
https://www.ncbi.nlm.nih.gov/pubmed/32314005
13.文章題目:Comparative study of intratracheal and oral gefitinib for the treatment of primary lung cancer.
期 刊:European Journal of Pharmaceutical Sciences(影響因子:3.532)
發(fā)表時(shí)間:18 April 2020
作 者:Zhang T, Wang R, Li M, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院放射醫(yī)學(xué)研究所
使用產(chǎn)品:Rat TNF-α ELISA Kit
樣本類型:支氣管肺泡灌洗液
https://www.sciencedirect.com/science/article/abs/pii/S092809872030141X
14.文章題目:Natural phenylethanoid glycosides isolated from Callicarpa kwangtungensis suppressed lipopolysaccharide-mediated inflammatory response via activating Keap1/Nrf2/HO-1 pathway in RAW 264.7 macrophages cell.
期 刊:Journal of Ethnopharmacology(影響因子:3.414)
發(fā)表時(shí)間:13 April 2020
作 者:Wu A, Yang Z, Huang Y, et al.
作者單位:廣州中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0378874119349177
15.文章題目:Phorbol myristate acetate induces cellular senescence in rat microglia in vitro.
期 刊:International Journal of Molecular Medicine(影響因子:2.928)
發(fā)表時(shí)間:23 April 2020
作 者:Cao D, Li X H, Luo X G, et al.
作者單位:沈陽市第四人民醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://www.spandidos-publications.com/10.3892/ijmm.2020.4587
16.文章題目:Pithecellobium clypearia extract enriched in gallic acid and luteolin has antibacterial activity against MRSA and reduces resistance to erythromycin, ceftriaxone sodium and levofloxacin.
期 刊:Journal of Applied Microbiology(影響因子:2.683)
發(fā)表時(shí)間:17 April 2020
作 者:Liu C, Huang H, Zhou Q, et al.
作者單位:中山大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-8 ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://www.ncbi.nlm.nih.gov/pubmed/32301544
17.文章題目:Oral immunization of BALB/c mice with recombinant Helicobacter pylori antigens and double mutant heat-labile toxin (dmLT) induces prophylactic protective immunity against H. pylori infection.
期 刊:Microbial Pathogenesis(影響因子:2.581)
發(fā)表時(shí)間:27 April 2020
作 者:Zhong Y, Chen J, Liu Y, et al.
作者單位:北京生物制品研究所
使用產(chǎn)品:Mouse IL-17, IL-16, IL-6 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0882401020305167
18.文章題目:IP10, KC and M-CSF is Remarkably Increased in the Brains from the Various Strains of Experimental Mice Infected with Different Scrapie Agents.
期 刊:Virologica Sinica(影響因子:2.467)
發(fā)表時(shí)間:20 April 2020
作 者:Chen J, Chen C, Hu C, et al.
作者單位:黑龍江八一農(nóng)墾大學(xué)
使用產(chǎn)品:Mouse IP-10, KC, M-CSF and human IP-10 ELISA Kits
樣本類型:小鼠大腦組織和人腦脊液
https://www.ncbi.nlm.nih.gov/pubmed/32314275
19.文章題目:Exosomes derived from M0, M1 and M2 macrophages exert distinct influences on the proliferation and differentiation of mesenchymal stem cells.
期 刊:PeerJ(影響因子:2.353)
發(fā)表時(shí)間:24 April 2020
作 者:Xia Y, He X T, Xu X Y, et al.
作者單位:第四軍醫(yī)大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-10 ELISA Kits
https://peerj.com/articles/8970.pdf
20.文章題目:High Glucose Induces the Loss of Retinal Pericytes Partly via NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis.
期 刊:BioMed Research International(影響因子:2.197)
發(fā)表時(shí)間:27 April 2020
作 者:Gan J, Huang M, Lan G, et al.
作者單位:西南醫(yī)科大學(xué)附屬醫(yī)院
使用產(chǎn)品:Human IL-1β and IL-18 ELISA Kits
https://www.hindawi.com/journals/bmri/2020/4510628/
21.文章題目:Wasp Venom Possesses Potential Therapeutic Effect in Experimental Models of Rheumatoid Arthritis.
期 刊:Evidence-Based Complementary and Alternative Medicine(影響因子:1.984)
發(fā)表時(shí)間:06 April 2020
作 者:Gao Y, Yu W X, Duan X M, et al.
作者單位:大理大學(xué)
使用產(chǎn)品:Rat IgA, IgG and IgM ELISA Kits
https://www.hindawi.com/journals/ecam/2020/6394625/
22.文章題目:Cytochrome P450 Epoxygenase 2J2 Protects Against Lung Ischemia/Reperfusion Injury by Activating the P13K/Akt/GSK-3-β/NF-kB Signaling Pathway During Deep Hypothermic Low Flow in Mice.
期 刊:Journal of Surgical Research(影響因子:1.872)
發(fā)表時(shí)間:16 April 2020
作 者:Yang Y, Wang J, Peng W, et al.
作者單位:南京醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6, IL-8, IL-10 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/pii/S0022480420300470
23.文章題目:Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis.
期 刊:The Clinical Respiratory Journal(影響因子:1.751)
發(fā)表時(shí)間:16 April 2020
作 者:Chen Y, Huang B, Zhao Y, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第二醫(yī)院
使用產(chǎn)品:Human IL-17, IL-6 and IL-10 ELISA Kits
https://www.ncbi.nlm.nih.gov/pubmed/32298537
24.文章題目:Bioactivity-guided isolation of anti-inflammatory components from Phyllanthus emblica.
期 刊:Food Science & Nutrition(影響因子:1.747)
發(fā)表時(shí)間:22 April 2020
作 者:Li W, Zhu H, Chen Y, et al.
作者單位:華南農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, and TNF-α ELISA Kits
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.1553