炎癥反應(yīng)是機體對損傷作出的一種保護性反應(yīng),其目的是將損傷源破壞、稀釋并清除,但與此同時也會引起不同程度的自身組織損傷。現(xiàn)有的抗炎藥,如皮質(zhì)類固醇和糖皮質(zhì)激素等,一般都有副作用,并會在炎癥組織中蓄積。四川大學(xué)王云兵教授團隊將潑尼松龍(Pred)通過ROS敏感鍵與雙光子熒光團(TP)橋接形成診斷治療化合物TPP,然后由兩親性聚合物PMPC-PMEMA(PMM)通過自組裝加載進核殼結(jié)構(gòu)的膠束(TPP@PMM)。TPP@PMM可以通過水腫組織實現(xiàn)在炎癥部位的積聚,并通過對局部過表達的ROS的系列反應(yīng)來準(zhǔn)確釋放抗炎藥物。此外,由于AIE活性熒光團TP,TPP @ PMM可以在體內(nèi)以獨特的雙光子高分辨率成像對炎癥進行追蹤。TPP@PMM作為急慢性炎癥治療的潛在策略,具有相當(dāng)大的前景。該研究成果以 ”Reactive Oxygen Species Responsive Theranostic Nanoplatform for Two-Photon Aggregation-Induced Emission Imaging and Therapy of Acute and Chronic Inflammation” 為題,發(fā)表在國際權(quán)威期刊《ACS Nano》上。
本文中使用了欣博盛Mouse IL-1β和TNF-α ELISA試劑盒,檢測了RAW 264.7細胞培養(yǎng)上清,小鼠支氣管肺泡灌洗液及小鼠關(guān)節(jié)組織和主動脈組織樣本的炎性細胞因子含量。 以下是欣博盛品牌產(chǎn)品5月SCI文獻引用整理:
1.文章題目:Reactive Oxygen Species Responsive Theranostic Nanoplatform for Two-Photon Aggregation-Induced Emission Imaging and Therapy of Acute and Chronic Inflammation.
期 刊:ACS Nano(影響因子:13.903)
發(fā)表時間:11 May 2020
作 者:Ma B, Xu H, Zhuang W, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Mouse IL-1β and TNF-α ELISA Kits
樣本類型:支氣管肺泡灌洗液,關(guān)節(jié)組織和主動脈組織
https://pubmed.ncbi.nlm.nih.gov/32379416
2.文章題目:Nanoenabled Disruption of Multiple Barriers in Antigen Cross-Presentation of Dendritic Cells via Calcium Interference for Enhanced Chemo-Immunotherapy.
期 刊:ACS Nano(影響因子:13.903)
發(fā)表時間:19 May 2020
作 者:An J, Zhang K, Wang B, et al.
作者單位:鄭州大學(xué)
使用產(chǎn)品:Mouse IFN-γ and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32427462
3.文章題目:A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions.
期 刊:Redox Biology(影響因子:7.793)
發(fā)表時間:11 May 2020
作 者:Lu M, Zhang X, Zhao J, et al.
作者單位:中國藥科大學(xué)
使用產(chǎn)品:Mouse IL-18 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/324225408
4.文章題目:Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis.
期 刊:Critical Care(影響因子:6.959)
發(fā)表時間:27 May 2020
作 者:Li M, Li C, Wu X, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6, IL-10, IL-12 and IL-22 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32460890
5.文章題目:TRPC6-dependent Ca 2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway.
期 刊:Cell death & disease(影響因子:5.959)
發(fā)表時間:May 2020
作 者:Chen Q, Zhou Y, Zhou L, et al.
作者單位:廣州醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-8 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32139669
6.文章題目:Necroptosis in head and neck squamous cell carcinoma: characterization of clinicopathological relevance and in vitro cell model.
期 刊:Cell Death & Disease(影響因子:5.959)
發(fā)表時間:22 May 2020
作 者:Li J, Huang S, Zeng L, et al.
作者單位:中山大學(xué)光華口腔醫(yī)學(xué)院
使用產(chǎn)品:Human IL-1β, IL-6 and IL-8 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32444644
7.文章題目:P2Y 14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages.
期 刊:Cell Death & Disease(影響因子:5.959)
發(fā)表時間:26 May 2020
作 者:Li H, Jiang W, Ye S, et al.
作者單位:中國藥科大學(xué)
使用產(chǎn)品:Human IL-1β ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/32457291
8.文章題目:Bisphenol A exposure induces gut microbiota dysbiosis and consequent activation of gut-liver axis leading to hepatic steatosis in CD-1 mice.
期 刊:Environmental Pollution(影響因子:5.714)
發(fā)表時間:29 May 2020
作 者:Feng D, Zhang H, Jiang X, et al.
作者單位:中山大學(xué)公共衛(wèi)生學(xué)院
使用產(chǎn)品:Mouse IL-1β, TNF-α, IL-6 and IL-18 ELISA Kits
https://www.sciencedirect.com/science/article/pii/S0269749120302736
9.文章題目:High-frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats.
期 刊:Journal of Neuroinflammation(影響因子:5.7)
發(fā)表時間:06 May 2020
作 者:Hong Y, Liu Q, Peng M, et al.
作者單位:南京大學(xué)醫(yī)學(xué)院附屬金陵醫(yī)院
使用產(chǎn)品:Rat TNF-α and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32375835
10.文章題目:A novel rapid modularized hepatitis B Core virus-like particle-based platform for personalized Cancer vaccine preparation via fixed-point coupling.
期 刊:Nanomedicine: Nanotechnology, Biology and Medicine(影響因子:5.57)
發(fā)表時間:16 May 2020
作 者:Ji M, Zhu J, Xie X, et al.
作者單位:中國科學(xué)院過程工程研究所
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-12 and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32422220
11.文章題目:ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses.
期 刊:Biomaterials Science(影響因子:5.251)
發(fā)表時間:04 May 2020
作 者:Qiu J, Peng P, Xin M, et al.
作者單位:中山大學(xué)孫逸仙紀(jì)念醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-6 and IFN-β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32363359/
12.文章題目:Cholesterol moieties as building blocks for assembling nanoparticles to achieve effective oral delivery of insulin.
期 刊:Biomaterials Science(影響因子:5.251)
發(fā)表時間:30 May 2020
作 者:Ding Y, Wang Q, Liu G, et al.
作者單位:中國藥科大學(xué)
使用產(chǎn)品:Porcine insulin ELISA Kit
https://pubs.rsc.org/en/Content/ArticleLanding/2020/BM/D0BM00577K#!divAbstract
13.文章題目:CD70-silenced dendritic cells induce immune tolerance in immune thrombocytopenia patients.
期 刊:British Journal of Haematology(影響因子:5.206)
發(fā)表時間:18 May 2020
作 者:Zhang X, Wang Y, Zhang D, et al.
作者單位:武漢大學(xué)中南醫(yī)院
使用產(chǎn)品:Human IFN-γ and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32419211
14.文章題目:Sophorasubprosrate polysaccharide suppress the inflammatory reaction of RAW264. 7 cells infected with PCV2 via regulation NF-κB/MAPKs/c-Jun signal pathway and histone acetylation modification.
期 刊:International Journal of Biological Macromolecules(影響因子:4.784)
發(fā)表時間:19 May 2020
作 者:Yang J, Cao M, Hu W, et al.
作者單位:廣西大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-10 ELISA Kits
https://www.sciencedirect.com/science/article/pii/S0141813020332669
15.文章題目:Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin.
期 刊:Stem Cell Research & Therapy(影響因子:4.627)
發(fā)表時間:19 May 2020
作 者:Yang X, Ma X, Don O, et al.
作者單位:上海交通大學(xué)醫(yī)學(xué)院附屬瑞金醫(yī)院
使用產(chǎn)品:Mouse IL-10 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/32429994
16.文章題目:Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages.
期 刊:Ecotoxicology and Environmental Safety(影響因子:4.527)
發(fā)表時間:20 May 2020
作 者:Luo Y, Peng J, Huang C, et al.
作者單位:湘潭大學(xué)
使用產(chǎn)品:Human MCP-1 and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32446100
17.文章題目:Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67.
期 刊:International Journal of Nanomedicine(影響因子:4.471)
發(fā)表時間:19 May 2020
作 者:Cui M, Jin M, Han M, et al.
作者單位:延邊大學(xué)附屬醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
18.文章題目:Chanling Gao attenuates bone cancer pain in rats by the IKKβ/NF-κB signaling pathway.
期 刊:Frontiers in Pharmacology(影響因子:3.845)
發(fā)表時間:5 May 2020
作 者:Yang B, Zhang Z, Yang Z, et al.
作者單位:貴州中醫(yī)藥大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Rat IL-6, TNF-α and IL-1β ELISA Kits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214814/
19.文章題目:Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis via the Liver HTR2A/PPARγ2 Pathway.
期 刊:Frontiers in Pharmacology(影響因子:3.845)
發(fā)表時間:14 May 2020
作 者:Wang L, Fan X, Han J, et al.
作者單位:中國藥科大學(xué)
使用產(chǎn)品:Rat TNF-α, IL-1β and IL-6 ELISA Kits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240039/
20.文章題目:Structural Characterization and Pro-inflammatory Activity of a Thaumatin-like Protein from the Pulp Tissues of Litchi chinensis.
期 刊:Journal of Agricultural and Food Chemistry(影響因子:3.571)
發(fā)表時間:15 May 2020
作 者:Chen H, Wang K, Xiao H, et al.
作者單位:華南農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-10 and TGF-β1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32412750
21.文章題目:High-Mobility Group Box 1 Promotes Epithelial-to-Mesenchymal Transition in Crystalline Silica Induced Pulmonary Inflammation and Fibrosis.
期 刊:Toxicology Letters(影響因子:3.499)
發(fā)表時間:17 May 2020
作 者:Ma J, Xu Y, Li W, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/32428545
22.文章題目:Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism.
期 刊:Journal of Ethnopharmacology(影響因子:3.414)
發(fā)表時間:14 May 2020
作 者:Yuan Z, Yang L, Zhang X, et al.
作者單位:甘肅農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-10, IL-4, TNF-α and IL-1β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32417423
23.文章題目:Guchang Zhixie Wan protects mice against dextran sulfate sodium-induced colitis through modulating the gut microbiota in colon.
期 刊:Journal of Ethnopharmacology(影響因子:3.414)
發(fā)表時間:20 May 2020
作 者:Wang Z, Liang Y, Yu J, et al.
作者單位:陜西中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-4, IL-6, IL-8 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/32442592
24.文章題目:Chemo-photodynamic therapy by pulmonary delivery of gefitinib nanoparticles and 5-aminolevulinic acid for treatment of primary lung cancer of rats.
期 刊:Photodiagnosis and Photodynamic Therapy(影響因子:2.589)
發(fā)表時間:11 May 2020
作 者:Zhang T, Bao J, Zhang M, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院放射醫(yī)學(xué)研究所
使用產(chǎn)品:Rat IL-6 and TNF-α ELISA Kits
樣本類型:肺組織勻漿
https://pubmed.ncbi.nlm.nih.gov/32404298
25.文章題目:Dehydrocorydaline inhibits the tumorigenesis of breast cancer MDA?MB?231 cells.
期 刊:Molecular Medicine Reports(影響因子:1.851)
發(fā)表時間:05 May 2020
作 者:Huang Y, Huang H, Wang S, et al.
作者單位:武漢市第五醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/32377708
26.文章題目:Effect of sitagliptin on expression of skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1 α and irisin in a rat model of type 2 diabetes mellitus.
期 刊:Journal of International Medical Research(影響因子:1.351)
發(fā)表時間:04 May 2020
作 者:Liu Y, Xu F, Jiang P.
作者單位:三峽大學(xué)仁和醫(yī)院
使用產(chǎn)品:Rat TNF-α ELISA Kit