免疫逃避是T細(xì)胞腫瘤免疫治療所面臨的主要障礙之一。腫瘤排斥抗原表達(dá)不足會(huì)導(dǎo)致固有免疫抵抗和干擾素γ (IFN-γ)誘導(dǎo)的程序性死亡配體1(PD-L1)高表達(dá)以進(jìn)一步誘導(dǎo)免疫抵抗。鑒于此,華東師范大學(xué)徐志愛(ài)教授和中科院上海藥物研究所于海軍研究員開(kāi)發(fā)了一種多功能前藥納米囊泡用于Doxy的腫瘤靶向遞送。該前藥納米囊泡具有可脫落的聚乙二醇?xì)雍虲RGDK配體,在血液循環(huán)中具有較高的穩(wěn)定性;該納米藥物能夠募集T淋巴細(xì)胞浸潤(rùn)腫瘤,并顯著抑制FN-γ誘導(dǎo)的瘤內(nèi)PD-L1表達(dá)。這一研究可為降低腫瘤免疫抵抗和增強(qiáng)腫瘤免疫治療提供一種新的靶向策略。
本研究中使用欣博盛小鼠IFN-γ ELISA試劑盒檢測(cè)了小鼠腫瘤組織中IFN-γ的分泌情況。
1.文章題目:Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer.
期 刊:Advanced Materials(影響因子:30.849)
發(fā)表時(shí)間:October 2021
作 者:Zhou F, Gao J, Tang Y, et al.
作者單位:上海藥物研究所
使用產(chǎn)品:Mouse IFN-γ ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34463392/
2.文章題目:Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms.
期 刊:Cell research(影響因子:25.617)
發(fā)表時(shí)間:26 October 2021
作 者:Zhu R, Yan T, Feng Y, et al.
作者單位:北京協(xié)和醫(yī)學(xué)院
使用產(chǎn)品:HRP-conjugated secondary antibody
https://pubmed.ncbi.nlm.nih.gov/34702946/
3.文章題目:Constructing nanocomplexes by multicomponent self-assembly for curing orthotopic glioblastoma with synergistic chemo-photothermal therapy.
期 刊:Biomaterials(影響因子:12.479)
發(fā)表時(shí)間:20 October 2021
作 者:Lu L, Wang K, Lin C, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/34700227/
4.文章題目:Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds.
期 刊:Journal of Nanobiotechnology(影響因子:10.435)
發(fā)表時(shí)間:2 October 2021
作 者:Sun H, Wang Y, He T, et al.
作者單位:昆明醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, TGF-β1, IL-1β, IL-6 and VEGF ELISA Kits
樣本類型:背部組織(TGF-β1)
https://pubmed.ncbi.nlm.nih.gov/34600530/
5.文章題目:Plasma EVs Display Antigen-Presenting Characteristics in Patients With Allergic Rhinitis and Promote Differentiation of Th2 Cells.
期 刊:Frontiers in immunology(影響因子:7.561)
發(fā)表時(shí)間:8 October 2021
作 者:Fang S B, Zhou Z R, Peng Y Q, et al.
作者單位:中山大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Human IL-13 high sensitivity ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34691024/
6.文章題目:Decreased miR-4512 Levels in Monocytes and Macrophages of Individuals With Systemic Lupus Erythematosus Contribute to Innate Immune Activation and Neutrsophil NETosis by Targeting TLR4 and CXCL2.
期 刊:Frontiers in Immunology(影響因子:7.561)
發(fā)表時(shí)間:14 October 2021
作 者:Yang B, Huang X, Xu S, et al.
作者單位:昆明醫(yī)科大學(xué)第二附屬醫(yī)院
使用產(chǎn)品:Human and mouse IL-1β, IL-2, IL-12, TNF-α, IFN-γ, IL-4, IL-6, IL-10 and IL-17 ELISA Kits
樣本類型:小鼠腎組織
https://pubmed.ncbi.nlm.nih.gov/34721432/
7.文章題目:Structure of water-soluble polysaccharides in spore of Ganoderma lucidum and their anti-inflammatory activity.
期 刊:Food Chemistry(影響因子:7.514)
發(fā)表時(shí)間:9 October 2021
作 者:Wen L, Sheng Z, Wang J, et al.
作者單位:中國(guó)科學(xué)院華南植物園
使用產(chǎn)品:Rat IL-1β and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34717092/
8.文章題目:Injectable Hydrogel Mediated Delivery of Gene-Engineered Adipose-Derived Stem Cells for Enhanced Osteoarthritis Treatment.
期 刊:Biomaterials Science(影響因子:6.843)
發(fā)表時(shí)間:5 October 2021
作 者:Yu W, Hu B, Boakye-Yiadom K O, et al.
作者單位:上海交通大學(xué)
使用產(chǎn)品:Human TGF-β1 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34671794/
9.文章題目:Deregulation of circ_003912 contributes to pathogenesis of erosive oral lichen planus by via sponging microRNA-123,-647 and-31 and upregulating FOXP3.
期 刊:Molecular Medicine(影響因子:6.354)
發(fā)表時(shí)間:20 October 2021
作 者:Huang Z, Liu F, Wang W, et al.
作者單位:南昌大學(xué)附屬口腔醫(yī)院
使用產(chǎn)品:Human IL-4, IFN-γ, IL-10 and IL-2 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34670484/
10.文章題目:CALR-TLR4 Complex Inhibits Non-Small Cell Lung Cancer Progression by Regulating the Migration and Maturation of Dendritic Cells.
期 刊:Frontiers in Oncology(影響因子:6.244)
發(fā)表時(shí)間:1 October 2021
作 者:Chen R, Huang M, Yang X, et al.
作者單位:空軍軍醫(yī)大學(xué)
使用產(chǎn)品:Human CCL19/MIP-3β ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34660305/
11.文章題目:Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s.
期 刊:Acta Pharmacologica Sinica(影響因子:6.15)
發(fā)表時(shí)間:20 October 2021
作 者:Li Y, Wang X, Su Y, et al.
作者單位:廣州中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-22 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34671110/
12.文章題目:Combination of Dexmedetomidine and Tramadol in Patient-Controlled Intravenous Analgesia Strengthens Sedative Effect in Pregnancy-Induced Hypertension.
期 刊:Frontiers in Pharmacology(影響因子:5.81)
發(fā)表時(shí)間:22 October 2021
作 者:Zhang S Y, Zhao H, Xu C, et al.
作者單位:廣州市紅十字會(huì)醫(yī)院
使用產(chǎn)品:Human IL-10 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34744722/
13.文章題目:Tanreqing Inhibits LPS-Induced Acute Lung Injury In Vivo and In Vitro Through Downregulating STING Signaling Pathway.
期 刊:Frontiers in Pharmacology(影響因子:5.81)
發(fā)表時(shí)間:14 October 2021
作 者:He Y Q, Zhou C C, Deng J L, et al.
作者單位:上海中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6, IL-1β and IFN-β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34721036/
14.文章題目:Fecal Microbiota Transplantation Modulates the Gut Flora Favoring Patients With Functional Constipation.
期 刊:Frontiers in Microbiology(影響因子:5.64)
發(fā)表時(shí)間:7 October 2021
作 者:Zhang X, Li N, Chen Q, et al.
作者單位:上海市第十人民醫(yī)院
使用產(chǎn)品:Human IL-4, IL-6, IL-8, IL-10 and IL-12p70 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34690948/
15.文章題目:Genetics and Clinical Characteristics of PPARγ Variant-Induced Diabetes in a Chinese Han Population.
期 刊:Frontiers in endocrinology(影響因子:5.555)
發(fā)表時(shí)間:26 October 2021
作 者:Gong S, Han X, Li M, et al.
作者單位:北京大學(xué)人民醫(yī)院
使用產(chǎn)品:Human Adiponectin ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34764936/
16.文章題目:Alleviation Effects of GQD, a Traditional Chinese Medicine Formula, on Diabetes Rats Linked to Modulation of the Gut Microbiome.
期 刊:Frontiers in cellular and infection microbiology(影響因子:5.293)
發(fā)表時(shí)間:8 October 2021
作 者:Tian J, Bai B, Gao Z, et al.
作者單位:中國(guó)中醫(yī)科學(xué)院廣安門醫(yī)院
使用產(chǎn)品:Rat IL-1β, TNF-α and MCP-1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34692563/
17.文章題目:Mycobacterium tuberculosis ESAT6 modulates host innate immunity by downregulating miR-222-3p target PTEN.
期 刊:Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease)(影響因子:5.187)
發(fā)表時(shí)間:25 October 2021
作 者:Zonghai C, Tao L, Pengjiao M, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34710568/
18.文章題目:Antigenicity and immunogenicity of recombinant proteins comprising African swine fever virus proteins p30 and p54 fused to a cell-penetrating peptide.
期 刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時(shí)間:29 October 2021
作 者:Zhang G, Liu W, Gao Z, et al.
作者單位:中國(guó)農(nóng)業(yè)科學(xué)院蘭州獸醫(yī)研究所
使用產(chǎn)品:Mouse IL-2, IFN-γ and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34715492/
19.文章題目:IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses.
期 刊:Journal of Immunology Research(影響因子:4.818)
發(fā)表時(shí)間:20 October 2021
作 者:Jiang H, Tsang L, Wang H, et al.
作者單位:南京大學(xué)
使用產(chǎn)品:Human IL-18 and CXCL10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34722780/
20.文章題目:Upregulation of CD22 by Chidamide promotes CAR T cells functionality.
期 刊:Scientific reports(影響因子:4.379)
發(fā)表時(shí)間:19 October 2021
作 者:Yang X, Yu Q, Xu H, et al.
作者單位:華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院
使用產(chǎn)品:Human IL-2, TNF-α, IFN-γ and GranzymeB ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34667217/
21.文章題目:Transcriptomic-based toxicological investigations of graphene oxide with modest cytotoxicity to human umbilical vein endothelial cells: changes of Toll-like receptor signaling pathways.
期 刊:Toxicology Research(影響因子:3.524)
發(fā)表時(shí)間:16 October 2021
作 者:Luo Y, Wang X, Cao Y.
作者單位:南華大學(xué)衡陽(yáng)醫(yī)學(xué)院
使用產(chǎn)品:Human IL-8 ELISA Kit
https://academic.oup.com/toxres/advance-article-abstract/doi/10.1093 /toxres/tfab091 /63985 38
22.文章題目:Comparison of P25 and nanobelts on Kruppel-like factor-mediated nitric oxide pathways in human umbilical vein endothelial cells.
期 刊:Journal of Applied Toxicology(影響因子:3.446)
發(fā)表時(shí)間:10 October 2021
作 者:Gu M, Wang S, Cao W, et al.
作者單位:南華大學(xué)衡陽(yáng)醫(yī)學(xué)院
使用產(chǎn)品:Human sICAM-1 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34633093/
23.文章題目:The Mechanism Exploration of Follicular Fluids on Granulose Cell Apoptosis in Endometriosis-Associated Infertility.
期 刊:BioMed Research International(影響因子:3.411)
發(fā)表時(shí)間:28 October 2021
作 者:Chen L, Ni Z, Cai Z, et al.
作者單位:海軍軍醫(yī)大學(xué)附屬長(zhǎng)海醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/34746304/
24.文章題目:Renoprotective Effect of Isoliquiritigenin on Cisplatin-induced Acute Kidney Injury Through Inhibition of FPR2 in Macrophage.
期 刊:Journal of Pharmacological Sciences(影響因子:3.337)
發(fā)表時(shí)間:9 October 2021
作 者:Rui-zhi T, Ke-huan X, Yuan L, et al.
作者單位:西南醫(yī)科大學(xué)附屬中醫(yī)醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/pii/S1347861321000967
25.文章題目:Transcriptomic analyses and Experimental verification reveal potential biomarkers and biological pathways of urinary tract infection.
期 刊:Bioengineered(影響因子:3.269)
發(fā)表時(shí)間:21 October 2021
作 者:Yang W, Liu P, Zheng Y, et al.
作者單位:長(zhǎng)春中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β and IL-6 ELISA Kits
樣本類型:腎組織
https://pubmed.ncbi.nlm.nih.gov/34592898/
26.文章題目:Zhikang Capsule Ameliorates Inflammation, Drives Polarization to M2 Macrophages, and Inhibits Apoptosis in Lipopolysaccharide-induced RAW264. 7 Cells.
期 刊:Current Medical Science(影響因子:2.135)
發(fā)表時(shí)間:27 October 2021
作 者:Xin S, Yang X, Zhang Y, et al.
作者單位:北京大學(xué)第一醫(yī)院
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34705217/
27.文章題目:High concentration of hydrogen ameliorates lipopolysaccharide-induced acute lung injury in a sirt1-dependent manner.
期 刊:Respiratory Physiology & Neurobiology(影響因子:1.931)
發(fā)表時(shí)間:28 October 2021
作 者:Du J, Li J, Li R, et al.
作者單位:河北醫(yī)科大學(xué)第二醫(yī)院
使用產(chǎn)品:Mouse IL-1β, TNF-α and IL-8 ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://www.sciencedirect.com/science/article/abs/pii/S1569904821001944