樹(shù)突狀細(xì)胞在腫瘤抗原的表達(dá)中起著關(guān)鍵作用,能啟動(dòng)天然和適應(yīng)性免疫反應(yīng)。而腫瘤微環(huán)境(Tumor Microenvironment,TME)包含抑制樹(shù)突狀細(xì)胞分化和成熟的免疫抑制因子網(wǎng)絡(luò)。免疫佐劑一直專注于調(diào)節(jié)樹(shù)突狀細(xì)胞的功能,以改善癌癥免疫治療。最近,澳門大學(xué)健康科學(xué)學(xué)院癌癥中心和轉(zhuǎn)化醫(yī)學(xué)研究所團(tuán)隊(duì)在期刊《Nano Today》(IF=20.722)上發(fā)表題為“Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy.”的文章,研究通過(guò)metal-phenolic coordination自組裝聲敏聚合物(PEG-b-IR)、谷胱甘肽抑制劑(sabutoclax)、Mn2+和TME酸敏酚聚合物(PEG-b-Pho),研制出了一種phenolic 納米佐劑。該佐劑展示了SDT介導(dǎo)的ICD效應(yīng)和Mn2+的聯(lián)合作用促進(jìn)了cGAS-STING通路的激活,顯著促進(jìn)了樹(shù)突狀細(xì)胞的成熟。此外,這種phenolic納米佐劑使腫瘤對(duì)PD-L1檢查點(diǎn)阻斷免疫療法高度敏感,從而有效抑制遠(yuǎn)處腫瘤的生長(zhǎng)并抑制肺轉(zhuǎn)移,為增強(qiáng)的癌癥免疫療法提供了彌補(bǔ)抗腫瘤免疫不足的治療局限性的潛力。
本文中使用了欣博盛Mouse IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, and IFN-β ELISA kits檢測(cè)了血清樣本中這些細(xì)胞因子的表達(dá)量。
1.文章題目:Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy.
期 刊:Nano Today(影響因子:20.722)
發(fā)表時(shí)間:25 January 2022
作 者:Tian H, Wang G, Sang W, et al.
作者單位:澳門大學(xué)健康科學(xué)學(xué)院癌癥中心和轉(zhuǎn)化醫(yī)學(xué)研究所
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, and IFN-β ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S1748013222000329
2.文章題目:Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
期 刊:Signal Transduction and Targeted Therapy(影響因子:18.187)
發(fā)表時(shí)間:20 January 2022
作 者:Wang Z, Zeng F, Hu Y, et al.
作者單位:四川大學(xué)華西醫(yī)學(xué)院
使用產(chǎn)品:Mouse MCP-1, IL-6, TNF-α , KC, IFN-γ, CXCL2 ELISA kit
樣本類型:結(jié)腸組織
https://pubmed.ncbi.nlm.nih.gov/35046386/
3.文章題目:Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion.
期 刊:Journal of Experimental Medicine(影響因子:14.307)
發(fā)表時(shí)間:21 January 2022
作 者:Cai Y, Wang Y, Shi C, et al.
作者單位:深圳大學(xué)醫(yī)學(xué)院
使用產(chǎn)品:Human Granzyme B ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35061012/
4.文章題目:Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer.
期 刊:Theranostics(影響因子:11.556)
發(fā)表時(shí)間:1 January 2022
作 者:Li X, Sun Z, Peng G, et al.
作者單位:中國(guó)醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所
使用產(chǎn)品:goat anti-rabbit IgG (H+L)-HRP
https://pubmed.ncbi.nlm.nih.gov/34976204/
5.文章題目:Dual-function injectable fibrin gel incorporated with sulfated chitosan nanoparticles for rhBMP-2-induced bone regeneration.
期 刊:Applied Materials Today(影響因子:10.041)
發(fā)表時(shí)間:5 January 2022
作 者:Chen X, Wang S, Zhang X, et al
作者單位:華東理工大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-4, IL-6, IL-10, TNFα, TGF-β1 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S2352940721003978
6.文章題目:Engineered Mesenchymal Stem Cells as a Biotherapy Platform for Targeted Photodynamic Immunotherapy of Breast Cancer.
期 刊:Advanced Healthcare Materials(影響因子:9.933)
發(fā)表時(shí)間:03 January 2022
作 者:Zhang H, Feng Y, Xie X, et al.
作者單位:中國(guó)電子科技大學(xué)生命科學(xué)與技術(shù)學(xué)院
使用產(chǎn)品:Mouse IL-12P70,IFN-γ and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/34981675/
7.文章題目:Construction of novel antiplatelet modified polyethersulfone membrane and study into its blood compatibility
期 刊:Materials Science and Engineering:C(影響因子:7.328)
發(fā)表時(shí)間:13 January 2022
作 者:Fu X, Lei T, Li S, et al.
作者單位: 中南大學(xué)
使用產(chǎn)品:Human IL-6, TNF-α, IL-10 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0928493122000194
8.文章題目:Delivery of nVEGFi using AAV8 for the treatment of neovascular age-related macular degeneration
期 刊:Molecular Therapy-Methods & Clinical Development(影響因子:6.698)
發(fā)表時(shí)間:10 January 2022.
作 者:She K, Su J, Wang Q, et al.
作者單位:四川大學(xué)華西醫(yī)院
使用產(chǎn)品:TMB底物
https://www.sciencedirect.com/science/article/pii/S2329050122000031
9.文章題目:PINK1 Kinase Enhances the Repair Effects of Bone Marrow Mesenchymal Stem Cells on Renal Ischemia/Reperfusion-Induced Acute Kidney Injury in Mice.
期 刊:Stem Cell Research & Therapy(影響因子:6.832)
發(fā)表時(shí)間:12 January 2022
作 者:Lin C, Chen W, Han Y, et al.
作者單位:河北北方大學(xué)基礎(chǔ)醫(yī)學(xué)院
使用產(chǎn)品:Mouse IL-10,TNF-α ELISA kits
https://www.researchsquare.com/article/rs-1242192/v1
10.文章題目: Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation
期 刊:International Journal of Nanomedicine(影響因子:6.4)
發(fā)表時(shí)間:6 January 2022
作 者:Chen Y, Zhang Q, Qin X, et al.
作者單位:南京醫(yī)科大學(xué)
使用產(chǎn)品:Human IL-1β, IL-6, IL-8, TNF-α ELISA kits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749050/
11.文章題目: Effects of polysaccharides from Fuzhuan brick tea on immune function and gut microbiota of cyclophosphamide-treated mice
期 刊:The Journal of Nutritional Biochemistry(影響因子:6.048)
發(fā)表時(shí)間:10 January 2022.
作 者:Bai Y, Zeng Z, Xie Z, et al
作者單位:南京農(nóng)業(yè)大學(xué)食品科學(xué)與技術(shù)學(xué)院
使用產(chǎn)品:Mouse TNF-α, IFN-γ and IgA ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35017006/
12.文章題目:Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway.
期 刊:Phytotherapy Research(影響因子:5.878)
發(fā)表時(shí)間:25 January 2022
作 者:Li G, Duan L, Yang F, et al.
作者單位:蘭州大學(xué)第二醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6, TNF-α ELISA kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/35080289/
13.文章題目:Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
期 刊:Biochemical Pharmacology(影響因子:5.858)
發(fā)表時(shí)間:12 January 2022
作 者:Tu Y, Tan L, Lu T, et al
作者單位:澳門大學(xué)粵港澳中醫(yī)藥及免疫疾病研究聯(lián)合實(shí)驗(yàn)室
使用產(chǎn)品:Human IL-8, MMP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35032460/
14.文章題目: An eco-friendly zein nanoparticle as robust cosmetic ingredient ameliorates skin photoaging
期 刊:Industrial Crops and Products(影響因子:5.645)
發(fā)表時(shí)間:11 January 2022
作 者:Zhu J J, Huang X N, Yang T, et al.
作者單位:華南理工大學(xué)
使用產(chǎn)品:Human TNF-α、IL-6 ELISA kit
https://www.sciencedirect.com/science/article/abs/pii/S0926669022000048
15.文章題目:Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathway.
期 刊:Phytomedicine(影響因子:5.34)
發(fā)表時(shí)間:10 January 2022
作 者:Feng Y, Zhu B, Liu Y, et al.
作者單位: 首都醫(yī)科大學(xué)北京地壇醫(yī)院
使用產(chǎn)品:Mouse TNF-α,IL-6,IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/34785108/
16.文章題目:Preventive effects of traditional Chinese medicine formula Huoxiangzhengqi against lipopolysaccharides-induced inflammatory response.
期 刊:Phytomedicine(影響因子:5.34)
發(fā)表時(shí)間:29 January 2022
作 者:Gao M, Zou Z, Qiu Y, et al.
作者單位:重慶醫(yī)科大學(xué)公共衛(wèi)生與管理學(xué)院
使用產(chǎn)品:Mouse IL-6 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0944711322000460
17.文章題目:Interactions Between Streptococcus gordonii and Fusobacterium nucleatum Altered Bacterial Transcriptional Profiling and Attenuated the Immune Responses of Macrophages
期 刊:Frontiers in Cellular and Infection Microbiology(影響因子:5.293)
發(fā)表時(shí)間:07 January 2022
作 者:Liu T, Yang R, Zhou J, et al.
作者單位:中山大學(xué)光華口腔醫(yī)學(xué)院口腔醫(yī)院
使用產(chǎn)品:Human IL-1β, IL-6, TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35071038/
18.文章題目:Discovery of Novel 2-Aryl-4-Bis-amide Imidazoles (ABAI) As Anti-inflammatory Agents for the Treatment of Inflammatory Bowel Diseases (IBD)
期 刊:Bioorganic Chemistry(影響因子:5.275)
發(fā)表時(shí)間:20 January 2022
作 者:Li L, Yuan S, Lin L, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Human IL-6 ,IL-1β, ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0045206822000244
19.文章題目: Isothermal RNA Amplification for the Detection of Viable Pathogenic Bacteria to Estimate the Salmonella Virulence for Causing Enteritis.
期 刊:Journal of Agricultural and Food Chemistry(影響因子:5.273)
發(fā)表時(shí)間:31 January 2022
作 者:Xue T, Lu Y, Yang H, et al.
作者單位: 四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Mouse IL-6, IFN-γ ELISA kits
https://pubs.acs.org/doi/abs/10.1021/acs.jafc.1c07182
20.文章題目:Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis期 刊:Cell Death Discovery(影響因子:5.241)
發(fā)表時(shí)間:17 January 2022
作 者:Li G, Lin Y, Zhang Y, et al.
作者單位:上海交通大學(xué)醫(yī)學(xué)院
使用產(chǎn)品:Human VEGF, IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35039492/
21.文章題目:Preparation, chemical structure, and immunostimulatory activity of a water-soluble heteropolysaccharide from Suillus granulatus fruiting bodies
期 刊: Food Chemistry: X(影響因子:5.182)
發(fā)表時(shí)間:15 January 2022
作 者:Gao X, Zeng R, Ho C T, et al.
作者單位:廣東省科學(xué)院微生物研究所
使用產(chǎn)品:Mouse TNF-α、IL-6、MCP-1 ELISA kits
https://www.sciencedirect.com/science/article/pii/S2590157522000098
22.文章題目:Dendrobium officinale Leaf Polysaccharides Ameliorated Hyperglycemia and Promoted Gut Bacterial Associated SCFAs to Alleviate Type 2 Diabetes in Adult Mice
期 刊: Food Chemistry: X(影響因子:5.182)
發(fā)表時(shí)間:10 January 2022.
作 者: Fang J, Lin Y, Xie H, et al.
作者單位:浙江工業(yè)大學(xué)食品科學(xué)與技術(shù)系
使用產(chǎn)品:Mouse IL-6, TNF-α ELISA kits
樣本類型:肝臟和結(jié)腸組織
https://www.sciencedirect.com/science/article/pii/S2590157522000050
23.文章題目:Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+ T cells
期 刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時(shí)間:10 January 2022.
作 者:Ding X, Le S, Wang K, et al.
作者單位:武漢大學(xué)
使用產(chǎn)品:Mouse IL-17A ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35026656/
24.文章題目:HSP60 regulates the cigarette smoke-induced activation of TLR4-NF-κB-MyD88 signalling pathway and NLRP3 inflammasome
期 刊:International immunopharmacology(影響因子:4.932)
發(fā)表時(shí)間:5 January 2022.
作 者:Ou G, Zhu M, Huang Y, et al.
作者單位:四川遂寧遂寧市中心醫(yī)院
使用產(chǎn)品:Mouse IL-1β, TNF-α, and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/34998273/
25.文章題目:MiR-124-3p targeting PDE4B attenuates LPS-induced ALI through the TLR4/NF-κB signaling pathway.
期 刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時(shí)間:18 January 2022.
作 者:Zhou Q, He D X, Deng Y L, et al.
作者單位: 四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Mouse IL-1β,TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35063752/
26.文章題目:PD-1 inhibitor causes pathological injury to multiple organs in a Lewis lung cancer mouse model.
期 刊: International Immunopharmacology(影響因子:4.932)
發(fā)表時(shí)間:22 January 2022
作 者:Chen Y, Liu Y, Xiong X, et al.
作者單位:南昌大學(xué)第二附屬醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35077961/
27.文章題目:Characterization and Evaluation of Antioxidant and Anti-Inflammatory Activities of Flavonoids from the Fruits of Lycium barbarum.
期 刊:Foods(影響因子:4.35)
發(fā)表時(shí)間:24 January 2022
作 者:Yang T, Hu Y, Yan Y, et al.
作者單位:南京農(nóng)業(yè)大學(xué)食品科學(xué)與技術(shù)學(xué)院
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6 ELISA kits
https://www.mdpi.com/2304-8158/11/3/306
28.文章題目:Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signaling.
期 刊:Authorea Preprints(影響因子:4.335)
發(fā)表時(shí)間:January 12, 2022
作 者:Yin W, Wu W, Jiao H, et al.
作者單位:南京大學(xué)
使用產(chǎn)品:Human Alpha Fetoprotein (AFP) ELISA kit
https://www.authorea.com/doi/full/10.22541/au.164201880.00585800
29.文章題目:Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3
期 刊:Environmental Toxicology(影響因子:4.119)
發(fā)表時(shí)間:21 January 2022
作 者:Liu F, Cheng X, Wu S, et al.
作者單位:浙江大學(xué)
使用產(chǎn)品:Human TNFα, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35061333/
30.文章題目:Antigenic and immunogenic properties of recombinant proteins consisting of two immunodominant African swine fever virus proteins fused with bacterial lipoprotein OprI
期 刊:Virology Journal (影響因子:4.099)
發(fā)表時(shí)間:21 January 2022
作 者:Zhang G, Liu W, Gao Z, et al.
作者單位:中國(guó)農(nóng)業(yè)科學(xué)院蘭州獸醫(yī)研究所
使用產(chǎn)品:Mouse IL-2, IFN-γ, TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35062983/
31.文章題目:Platelet protects angiotensin II-driven abdominal aortic aneurysm formation through inhibition of inflammation
期 刊:Experimental Gerontology(影響因子:4.032)
發(fā)表時(shí)間:14 January 2022.
作 者:Liu X, Chen X, Xu C, et al.
作者單位:杭州市浙江醫(yī)院心內(nèi)科
使用產(chǎn)品:Mouse TNF-α, IL-1β, and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35038567/
32.文章題目: Anti‐diabetic and gut microbiota modulation effects of sacha inchi (Plukenetia volubilis L.) leaf extract in streptozotocin‐induced type 1 diabetic mice
期 刊:Journal of the Science of Food and Agriculture(影響因子:3.638)
發(fā)表時(shí)間:19 January 2022
作 者:Lin J, Wen J, Xiao N, et al.
作者單位:華南農(nóng)業(yè)大學(xué)食品學(xué)院
使用產(chǎn)品:Human insulin ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35043419/
33.文章題目: Immunological Risk Assessment of Xenogeneic Dural Patch by Comparing with Raw Material via GTKO Mice
期 刊: BioMed Research International(影響因子:3.411)
發(fā)表時(shí)間:17 January 2022
作 者:Mu Y, Shao A, Shi L, et al.
作者單位:西南交通大學(xué)材料科學(xué)與工程學(xué)院
使用產(chǎn)品:Mouse IgG、IgM ELISA kits
https://www.hindawi.com/journals/bmri/2022/7950834/
34.文章題目: FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells
期 刊:Military Medical Research(影響因子:3.329)
發(fā)表時(shí)間:29 January 2022
作 者:Tan Y Y, Zhou H Q, Lin Y J, et al.
作者單位:中山大學(xué)附屬第五醫(yī)院
使用產(chǎn)品:BSA
https://pubmed.ncbi.nlm.nih.gov/35093168/
35.文章題目:Loss of JNK-Associated Leucine Zipper Protein Promotes Peritoneal Dialysis-Related Peritoneal Fibrosis
期 刊: Kidney Diseases (影響因子:3.222)
發(fā)表時(shí)間:1 January 2022
作 者:Tian M, Zhang L, Wang Y, et al.
作者單位:武漢大學(xué)人民醫(yī)院
使用產(chǎn)品:Human TGF-β1 ELISA kit
https://www.karger.com/Article/FullText/521564
36.文章題目: Inflammatory level under different p53 mutation status and the regulation role of curcumin in tumor microenvironment.
期 刊: Immunobiology,(影響因子:3.144)
發(fā)表時(shí)間:7 January 2022.
作 者:Xu L, Xie X, Li X, et al.
作者單位:昆明理工大學(xué)生命科學(xué)與技術(shù)學(xué)院
使用產(chǎn)品:Human IL6 ,M- CSF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35030341/
37.文章題目:FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA
期 刊:Molecular Medicine Reports(影響因子:2.952)
發(fā)表時(shí)間:21 January 2022
作 者:Yang B, Liu D, Ren Y Q, et al.
作者單位:山西醫(yī)科大學(xué)第一醫(yī)院
使用產(chǎn)品:Human VEGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35059733/
38.文章題目: The recombinant pseudorabies virus expressing porcine deltacoronavirus spike protein is safe and effective for mice
期 刊:BMC veterinary research(影響因子:2.741)
發(fā)表時(shí)間:04 January 2022
作 者:Huang Y, Xu Z, Gu S, et al.
作者單位:四川農(nóng)業(yè)大學(xué)獸醫(yī)學(xué)院
使用產(chǎn)品:Mouse IL-4, IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/34983523/
39.文章題目:Long Non-coding RNA GAS5/miR-520-3p/SOCS3 Axis Regulates Inflammatory Response in Lipopolysaccharide-Induced Macrophages.
期 刊:Biochemical Genetics(影響因子:1.89)
發(fā)表時(shí)間:31 January 2022
作 者:Du J, Jiang H, Wang B.
作者單位:長(zhǎng)江大學(xué)第二臨床醫(yī)學(xué)院
使用產(chǎn)品:Human IL-6, IL-1β, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35098408/