越來越多的證據(jù)表明空氣污染和關(guān)節(jié)病之間有著密切的聯(lián)系。雖然超細(xì)顆粒(ultrafine particles, UFPs)對關(guān)節(jié)的間接影響,即通過誘導(dǎo)炎性細(xì)胞因子,已經(jīng)被證實,但是在理解外來顆粒對關(guān)節(jié)的直接威脅方面仍然存在空白。最近,中國科學(xué)院生態(tài)環(huán)境科學(xué)研究中心團(tuán)隊在期刊《Nano Today》(IF=20.722)上發(fā)表題為“Intrusion of inhaled exotic ultrafine particles into the knee joint in humans and animals: A risk to the joint and surrounding tissues.”的文章,在骨關(guān)節(jié)炎患者的人類膝關(guān)節(jié)積液中發(fā)現(xiàn)了外來的 UFPs,并通過計算它們的化學(xué)和結(jié)構(gòu)指紋來識別這些 UFPs的周圍環(huán)境暴露源,包括天然礦物和金屬氧化物顆粒(即銅鎳礦和赤鐵礦)。此外,動物實驗揭示了吸入的 UFPs轉(zhuǎn)移到關(guān)節(jié)中。組織學(xué)檢查發(fā)現(xiàn)關(guān)節(jié)中UFPs的侵入對滑膜和軟骨造成了明顯的損傷。借助于同位素標(biāo)記,研究者證實了 UFPs在關(guān)節(jié)中的侵入,并獲得了相應(yīng)的小鼠retention kinetics。該研究成果提供了外來顆粒侵入關(guān)節(jié)腔的直接證據(jù),并確定了吸入的 UFPs從吸入系統(tǒng)轉(zhuǎn)移到關(guān)節(jié)和關(guān)節(jié)保護(hù)系統(tǒng)的損傷。這項研究提供了空氣污染對關(guān)節(jié)的不利影響額外的見解,并對特別是與空氣污染有關(guān)的公共衛(wèi)生措施具有至關(guān)重要的意義。
本文中使用了欣博盛Mouse IL-6 ELISA kits檢測了血清樣本中的表達(dá)量。
1.文章題目:Intrusion of inhaled exotic ultrafine particles into the knee joint in humans and animals: A risk to the joint and surrounding tissues.
期 刊:Nano Today(影響因子:20.722)
發(fā)表時間:11 February 2022
作 者:Yu Qi, Shuting Wei, Yucai Chen, et al.
作者單位:中國科學(xué)院生態(tài)環(huán)境科學(xué)研究中心
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://www.sciencedirect.com/science/article/pii/S1748013222000536
2.文章題目:Bioinspired magnetic nanocomplexes amplifying STING activation of tumor-associated macrophages to potentiate cancer immunotherap.
期 刊:Nano Today(影響因子:20.722)
發(fā)表時間:22 January 2022
作 者:Li T, Song R, Sun F, et al.
作者單位:同濟大學(xué)醫(yī)學(xué)院附屬第十人民醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-6 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S1748013222000275
3.文章題目:A Triple‐Kill Strategy for Tumor Eradication Reinforced by Metal‐Phenolic Network Nanopumps.
期 刊: Advanced Functional Materials(影響因子:18.808)
發(fā)表時間:10 February 2022
作 者:Sang W, Zhang Z, Wang G, et al.
作者單位:澳門大學(xué)健康科學(xué)學(xué)院癌癥中心及轉(zhuǎn)化醫(yī)學(xué)研究所
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6, IL-10, IL-12p70 ELISA kits
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202113168
3.文章題目:Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.
期 刊:Signal Transduction and Targeted Therapy(影響因子:18.187)
發(fā)表時間:23 February 2022
作 者:Jin Y, Kang Y, Wang M, et al.
作者單位:華中科技大學(xué)
使用產(chǎn)品:Human IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35194016/
4.文章題目:Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine Efficiency
期 刊:Advanced Science(影響因子:16.806)
發(fā)表時間:10 February 2022
作 者:Wang Y, Zhao Q, Zhao B, et al.
作者單位:福州大學(xué)
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-2 ELISA kits.
https://pubmed.ncbi.nlm.nih.gov/35142445/
5.文章題目:Cubic multi-ions-doped Na2TiO3 nanorod-like coatings: Structure-stable, highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition.
期 刊:Bioactive Materials(影響因子:14.593)
發(fā)表時間:15 February 2022
作 者:Yu D, Li B, Yu M, et al.
作者單位:西安交通大學(xué)
使用產(chǎn)品:Human total HIF-1α ELISA kit
https://www.sciencedirect.com/science/article/pii/S2452199X22000470
6.文章題目:Lenvatinib-and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer.
期 刊:Acta Pharmaceutica Sinica B(影響因子:11.413)
發(fā)表時間:25 February 2022
作 者:Zheng C, Zhang W, Wang J, et al.
作者單位:中國科學(xué)院上海藥物研究所
使用產(chǎn)品:Mouse IL-12p40, IFN-γ, TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S2211383522000776
7.文章題目:Self-oxygenation mesoporous MnO2 nanoparticles with ultra-high drug loading capacity for targeted arteriosclerosis therapy.
期 刊:Journal of Nanobiotechnology(影響因子:10.435)
發(fā)表時間:19 February 2022
作 者:Sun W, Xu Y, Yao Y, et al.
作者單位:哈爾濱醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6, MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35183183/
8.文章題目:Targeting and promoting atherosclerosis regression using hybrid membrane coated nanomaterials via alleviated inflammation and enhanced autophagy.
期 刊:Applied Materials Today(影響因子:10.041)
發(fā)表時間:2 February 2022
作 者:You P, Mayier A, Zhou H, et al.
作者單位:寧夏醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6, MCP-1, IL-10 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S2352940722000257
9.文章題目:Tollip orchestrates macrophage polarization to alleviate intestinal mucosal inflammation.
期 刊:Journal of Crohn's and Colitis(影響因子:9.071)
發(fā)表時間:3 February 2022
作 者:Liu X, Ren X, Zhou L, et al.
作者單位:南方醫(yī)科大學(xué)南方醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6, IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35134154/
10.文章題目:LncRNA Neat1 promotes the macrophage inflammatory response and acts as a therapeutic target in titanium particle-induced osteolysis.
期 刊:Acta Biomaterialia(影響因子:8.947)
發(fā)表時間:10 February 2022
作 者:Lin S, Wen Z, Li S, et al.
作者單位:中山大學(xué)孫逸仙紀(jì)念醫(yī)院
使用產(chǎn)品:Mouse , TNF-α, IL-1β, IFN-β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35151924/
11.文章題目:Sulfated heteropolysaccharides from Undaria pinnatifida: Structural characterization and transcript-metabolite profiling of immunostimulatory effects on RAW264. 7 cells.
期 刊:Food Chemistry: X(影響因子:7.514)
發(fā)表時間:12 February 2022
作 者:Yang L, Liu J, Xia X, et al.
作者單位:華南農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-6, TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S2590157522000499
12.文章題目:A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy.
期 刊:Molecular Therapy-Oncolytics(影響因子:7.2)
發(fā)表時間:20 February 2022
作 者:Muhammad N, Wang R, Li W, et al.
作者單位:陜西師范大學(xué)
使用產(chǎn)品:Human IFN-γ, IL-2 ELISA kits
https://www.sciencedirect.com/science/article/pii/S2372770522000298
13.文章題目:The Attenuation of Chronic Ulcerative Colitis by (R)-salbutamol in Repeated DSS-Induced Mice.
期 刊:Oxidative Medicine and Cellular Longevity(影響因子:6.543)
發(fā)表時間:7 February 2022
作 者:Deng L, Guo H, Wang S, et al.
作者單位:廣東工業(yè)大學(xué)生物醫(yī)學(xué)與藥物科學(xué)研究所
使用產(chǎn)品:Mouse IFN-γ, IL-1β, IL-6, TNF-α ELISA kits
https://www.hindawi.com/journals/omcl/2022/9318721/#data-availability
14.文章題目:Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis.
期 刊:European Journal of Medicinal Chemistry(影響因子:6.514)
發(fā)表時間:17 February 2022
作 者:Jiao Y, Nan J, Mu B, et al.
作者單位:四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Human IL-1β, IL-18, TNF-α ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0223523422000964
15.文章題目:Porous Bioactive Prosthesis With Chitosan/Mesoporous Silica Nanoparticles Microspheres Sequentially and Sustainedly Releasing Platelet-Derived Growth Factor-BB and Kartogenin: A New Treatment Strategy for Osteoarticular Lesions.
期 刊:Frontiers in Bioengineering and Biotechnology(影響因子:5.89)
發(fā)表時間:3 February 2022
作 者:Yuan Z, Lyu Z, Zhang W, et al.
作者單位: 四川大學(xué)
使用產(chǎn)品:Human PDGF-BB ELISA kits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850694/
16.文章題目:Network Pharmacology and Molecular Docking Analysis on Molecular Mechanism of Qingzi Zhitong Decoction in The Treatment of Ulcerative Colitis .
期 刊:Frontiers in Pharmacology(影響因子:5.81)
發(fā)表時間:8 February 2022,
作 者:Shou X, Wang Y, Zhang X S, et al.
作者單位:首都醫(yī)科大學(xué)
使用產(chǎn)品:Rat TNF-α ELISA kits
樣本類型:結(jié)腸組織
https://www.frontiersin.org/articles/10.3389/fphar.2022.727608/pdf
17.文章題目:Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.
期 刊:Frontiers in Aging Neuroscience(影響因子:5.75)
發(fā)表時間:9 February 2022
作 者:He K, Zhang J, Zhang W, et al.
作者單位:中國科學(xué)技術(shù)大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6 ELISA kits
樣本類型:海馬組織
https://www.proquest.com/openview/
18.文章題目:Dietary Linolenic Acid Increases Sensitizing and Eliciting Capacities of Cow’s Milk Whey Proteins in BALB/c Mice.
期 刊:Nutrients(影響因子:5.717)
發(fā)表時間:16 February 2022
作 者:Meng X, Wu Y, Wen X, et al.
作者單位:南昌大學(xué)
使用產(chǎn)品:TMB底物, Mouse MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35215473/
19.文章題目:Preliminary Report on Intestinal Flora Disorder, Faecal Short-Chain Fatty Acid Level Decline and Intestinal Mucosal Tissue Weakening Caused by Litchi Extract to Induce Systemic Inflammation in HFA Mice.
期 刊:Nutrients(影響因子:5.717)
發(fā)表時間:12 February 2022
作 者:Sun D, Wang C, Sun L, et al.
作者單位:廣東海洋大學(xué)食品科技學(xué)院
使用產(chǎn)品:Mouse TNF-α, IFN-γ, IL-1β, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35215426/
20.文章題目:Bioactive triple peptide inhibits inflammasome activation to alleviate Salmonella-induced intestinal inflammation in mice via modulation of host defense and bacterial virulence.
期 刊:Food & Function(影響因子:5.396)
發(fā)表時間:9 February 2022
作 者:Cui C, Liu Q, Duan B, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Human IL-1β ELISA kits
https://pubs.rsc.org/en/content/articlehtml/2022/fo/d1fo03891e
21.文章題目:Pathogenic Tconvs promote inflammatory macrophage polarization through GM‐CSF and exacerbate abdominal aortic aneurysm formation.
期 刊:The FASEB Journal(影響因子:5.191)
發(fā)表時間:8 February 2022
作 者:Li D, Li J, Liu H, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院
使用產(chǎn)品:Mouse CCL2, GM-CSF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35133017/
22.文章題目:Mechanism of SMND-309 against lung injury induced by chronic intermittent hypoxia.
期 刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時間:1 February 2022
作 者:Hou Y, Xu N, Li S, et al.
作者單位:濱州醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-1β, TNF-α, TGF-β, IL-4, IL-10 ELISA kits
樣本類型:肺組織
https://pubmed.ncbi.nlm.nih.gov/35121224/
23.文章題目:A Variation in SORBS1 is Associated with Type 2 Diabetes and High‐density Lipoprotein Cholesterol in Chinese Population
期 刊:Diabetes/Metabolism Research and Reviews(影響因子:4.876)
發(fā)表時間:02 February 2022
作 者:Gong S, Huo S, Luo Y, et al.
作者單位:北京大學(xué)人民醫(yī)院
使用產(chǎn)品:Human Adiponectin ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35107206/
24.文章題目:Platelets inhibit development of atherosclerosis in atherosclerotic mice.
期 刊:Cell Cycle(影響因子:4.534)
發(fā)表時間:15 February 2022
作 者:Liu X, Bao Y, Lin Z, et al.
作者單位:浙江中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6, MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35213268/
25.文章題目:Integrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice.
期 刊:Journal of Functional Foods(影響因子:4.451)
發(fā)表時間:3 February 2022
作 者:Ji J, Zhang S, Tang L, et al.
作者單位:貴州醫(yī)科大學(xué)藥學(xué)院
使用產(chǎn)品:Rat TNF-α、IL-6 ELISA kits
https://www.sciencedirect.com/science/article/pii/S1756464622000482
26.文章題目:Metal (Au)-Decorated Chitosan-l-Arginine Polymeric Vector for Codelivery of Gefitinib and miR125b for Lung Cancer Therapy.
期 刊:ACS Applied Polymer Materials(影響因子:4.442)
發(fā)表時間:15 February 2022
作 者:Amgoth C, He Y, Wang S, et al
作者單位:浙江大學(xué)
使用產(chǎn)品:Mouse EGF, VEGF, MMP-9 ELISA kits
https://pubs.acs.org/doi/abs/10.1021/acsapm.1c01515
27.文章題目: FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner.
期 刊:Molecular Immunology (影響因子:4.407)
發(fā)表時間:4 February 2022
作 者:Huang Z, Pu J, Luo Y, et al.
作者單位:重慶醫(yī)科大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-1β, TNF-α, IL6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35131594/
28.文章題目:SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis.
期 刊:Clinical and Experimental Immunology(影響因子:4.33)
發(fā)表時間:2 February 2022
作 者:Xie Y, Jiang X, Wang P, et al.
作者單位:北京大學(xué)人民醫(yī)院
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://academic.oup.com/cei/advance-article/doi/10.1093/cei/uxac010/6520539?login=false
29.文章題目:Curcumin assists anti-EV71 activity of IFN-α by inhibiting IFNAR1 reduction in SH-SY5Y cells.
期 刊:Gut Pathogens(影響因子:4.181)
發(fā)表時間:12 February 2022
作 者:Wang Y, Dan K, Xue X, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Human IFN-α, IFN-β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35151347/
30.文章題目:A20 alleviated caspase-1-mediated pyroptosis and inflammation stimulated by Porphyromonas gingivalis lipopolysaccharide and nicotine through autophagy enhancement.
期 刊:Human Cell(影響因子:4.174)
發(fā)表時間:25 February 2022
作 者:Tang H, Ye Y, Li L, et al.
作者單位:南京醫(yī)科大學(xué)
使用產(chǎn)品:Human IL-1β, IL-18, TNFα,IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35212946/
31.文章題目:Exploration of the Function of Ginsenoside RD Attenuates Lipopolysaccharide-Induced Lung Injury: A Study of Network Pharmacology and Experimental Validation.
期 刊:Shock(影響因子:3.454)
發(fā)表時間:7 February 2022
作 者:Yang B, Wang R, Ji L L, et al.
作者單位:天津醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-a, IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/34172615/
32.文章題目:Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.
期 刊:PloS one(影響因子:3.24)
發(fā)表時間:2 February 2022
作 者:Liu L, Fu Q, Li T, et al.
作者單位:山東大學(xué)齊魯醫(yī)院
使用產(chǎn)品:Human insulin, leptin ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35108315/
33.文章題目:Ganoderic acid A ameliorates non?alcoholic streatohepatitis (NASH) induced by high?fat high?cholesterol diet in mice.
期 刊:Experimental and Therapeutic Medicine(影響因子:2.447)
發(fā)表時間:24 February 2022
作 者:Zhu J, Ding J, Li S, et al.
作者單位:浙江中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, TNF-α ELISA kits
https://www.spandidos-publications.com/10.3892/etm.2022.11237
34.文章題目:Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation.
期 刊:Research(影響因子:1.139)
發(fā)表時間:4 February 2022
作 者:Cao T, Shao C, Yu X, et al.
作者單位:浙江省再生醫(yī)學(xué)、視覺和腦健康實驗室
使用產(chǎn)品:Human IL-6, IL-7, IL-8, TNF-α, ICAM-1, VEGF ELISA kits
https://downloads.spj.sciencemag.org/research/2022/9819154.pdf