近期,中國醫(yī)學(xué)科學(xué)院皮膚病研究所姚煦教授團隊、復(fù)旦大學(xué)附屬華山醫(yī)院李巍教授團隊及香港城市大學(xué)董立新教授團隊合作在Cell Host & Microbe(IF=20.6)上發(fā)表題為“Multi-omics Signatures Reveal Genomic and Functional Heterogeneity of Cutibacterium acnes in Normal and Diseased Skin.”(多組學(xué)特征揭示正常和患病皮膚中痤瘡丙酸桿菌的基因組和功能異質(zhì)性)的研究,在該項目中,研究團隊從1234個分離基因組中證明了C. acnes的個體和生態(tài)位異質(zhì)性。皮膚疾?。裾詈宛畀彛┖蜕眢w部位決定了C. acnes的基因組差異,這種差異源于水平基因轉(zhuǎn)移和選擇壓力。與表皮葡萄球菌(Staphylococcus epidermidis)相比,C. acnes具有獨特的代謝功能,抗生素耐藥基因和毒力因子較少,基因組更穩(wěn)定。
綜合基因組、轉(zhuǎn)錄組和代謝組分析在菌株水平揭示了C. acnes的功能特征。與轉(zhuǎn)錄組特征一致,C. acnes在富含皮脂的環(huán)境中對角質(zhì)形成細胞產(chǎn)生毒性和促炎作用。L-肌肽(L-carnosine)是一種抗氧化應(yīng)激代謝物,在濕疹的代謝組中上調(diào)并減輕皮膚炎癥。總的來說,該研究揭示了基因和微環(huán)境對C. acnes功能的共同影響。利用從健康皮膚、濕疹(AD)和痤瘡患者皮膚分離的痤瘡丙酸桿菌(Cutibacterium acnes, C. acnes)菌株進行了全基因組測序、轉(zhuǎn)錄組測序、代謝組測序以及功能研究,研究團隊首次從單菌株層面揭示了C. acnes的基因和功能異質(zhì)性。通過深入地了解宿主和皮膚微生物群之間的復(fù)雜關(guān)系,有望能找到增進皮膚健康和改善皮膚病管理的靶點,也為將來探索C. acnes的臨床應(yīng)用奠定了基礎(chǔ)。
該項研究中,使用了欣博盛生物(NeoBioscience Technology Co, Ltd)的Mouse IgE, IL-4, IL-6, IL-13 and IL-33 ELISA Kits,用于檢測小鼠血樣中相關(guān)指標(biāo)的含量。
貨號 | 產(chǎn)品名稱 | 靈敏度 | 檢測范圍 |
QuantiCyto? Mouse IgE ELISA Kit(小鼠免疫球蛋白E) | 0.78ng/ml | 1.56-100ng/ml | |
QuantiCyto? Mouse IL-4 ELISA kit(小鼠白細胞介素-4) | 3.9pg/ml | 7.8-500pg/ml | |
QuantiCyto? Mouse IL-6 ELISA kit(小鼠白細胞介素-6) | 7.8pg/ml | 15.6-1000pg/ml | |
QuantiCyto? Mouse IL-13 ELISA kit(小鼠白細胞介素-13) | 2.344 pg/ml | 4.688-300pg/ml | |
EMC110 | QuantiCyto? Mouse IL-33 ELISA kit(小鼠白細胞介素-33) | 23.44pg/ml | 46.875-3000pg/ml |
欣博盛生物非常榮幸能夠作為供應(yīng)商為該項研究提供高品質(zhì)ELISA試劑盒,為生物醫(yī)學(xué)領(lǐng)域的科研探索貢獻一份力量。
2024年6月文獻引用
1. Multi-omics signatures reveal genomic and functional heterogeneity of Cutibacterium acnes in normal and diseased skin.(Cell Host & Microbe, IF=20.6)
發(fā)表時間:2024/6/26
作者:Yu T, Xu X, Liu Y, et al.
作者單位:復(fù)旦大學(xué)附屬華山醫(yī)院
使用產(chǎn)品:Mouse IgE, IL-4, IL-6, IL-13 and IL-33 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38936370/
2. Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion.(ACS nano, IF=15.8)
發(fā)表時間:2024/6/4
作者:Wang B, Tang M, Chen Q, et al.
作者單位:上海交通大學(xué)
使用產(chǎn)品:Mouse IL-12, IL-2, TNF-α and IFN-γ ELISA Kits
樣本類型:腫瘤組織
https://pubmed.ncbi.nlm.nih.gov/38832815/
3. Nonswellable Hydrogel Patch with Tissue-Mimetic Mechanical Characteristics Remodeling In Vivo Microenvironment for Effective Adhesion Prevention.(ACS nano, IF=15.8)
發(fā)表時間:2024/6/27
作者:Liu X, Qiu X, Nie L, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits
樣本類型:條件培養(yǎng)基
https://pubmed.ncbi.nlm.nih.gov/38932673/
4. Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses.(Acta Pharmaceutica Sinica B, IF=14.7)
發(fā)表時間:2024/6/20
作者:Yin L, Zhang E, Mao T, et al.
作者單位:中國藥科大學(xué)
使用產(chǎn)品:Mouse IL-27 and IFN-γ ELISA Kits
https://www.sciencedirect.com/science/article/pii/S2211383524002399
5. Choroid plexus CCL2?CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.(Acta Pharmaceutica Sinica B, IF=14.7)
發(fā)表時間:2024/6/26
作者:Wang Q, Liu F, Li Y, et al.
作者單位:四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Rat CCL2, TNF-α and IL-1β ELISA Kits
樣本類型:腦脊液
https://www.sciencedirect.com/science/article/pii/S221138352400251X
6. PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma.(Nature Communications, IF=14.7)
發(fā)表時間:2024/6/21
作者:Huang S Y, Gong S, Zhao Y, et al.
作者單位:中山大學(xué)腫瘤防治中心
使用產(chǎn)品:Mouse IL-1α, IL-6 and CXCL10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38906860/
7. Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer.(Nature Communications, IF=14.7)
發(fā)表時間:2024/6/17
作者:Bai H, Liu X, Lin M, et al.
作者單位:西湖大學(xué)
使用產(chǎn)品:Histostain-Plus IHC Kit
https://pubmed.ncbi.nlm.nih.gov/38886378/
8. T Cell-Derived Apoptotic Extracellular Vesicles Hydrolyze cGAMP to Alleviate Radiation Enteritis via Surface Enzyme ENPP1.(Advanced Science, IF=14.3)
發(fā)表時間:2024/6/18
作者:Zhou Y, Bao L, Gong S, et al.
作者單位:西北大學(xué)
使用產(chǎn)品:Mouse IL-10 and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38888507/
9. Reversing MET-Mediated Resistance in Oncogene-Driven NSCLC by MET-Activated Wnt Condensative Prodrug.(Advanced Science, IF=14.3)
發(fā)表時間:2024/6/13
作者:Liu N, Zheng X, Yan J, et al.
作者單位:西安交通大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-2, IL-6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38867713/
10. Chemical conjugation mitigates immunotoxicity of chemotherapy via reducing receptor-mediated drug leakage from lipid nanoparticles.(Science Advances, IF=11.7)
發(fā)表時間:2024/6/5
作者:Zheng C, Zhang W, Gong X, et al.
作者單位:中國科學(xué)院上海藥物研究所
使用產(chǎn)品:Mouse TNF-α, IFN-γ, and IL-12p40 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38838152/
11. Pulmonary fibroblast-specific delivery of siRNA exploiting exosomes-based nanoscaffolds for IPF treatment.(Asian Journal of Pharmaceutical Sciences, IF=10.7)
發(fā)表時間:2024/6/11
作者:Lu H, Liu X, Zhang M, et al.
作者單位:沈陽藥科大學(xué)
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits
樣本類型:支氣管灌洗液
https://www.sciencedirect.com/science/article/pii/S1818087624000461
12. CircMALAT1 promotes cancer stem-like properties and chemoresistance via regulating Musashi-2/c-Myc axis in esophageal squamous cell carcinoma.(MedComm, IF=10.7)
發(fā)表時間:2024/6/14
作者:Zhao Z, Deng Y, Han J, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/38881674/
13. EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion.(Journal for ImmunoTherapy of Cancer, IF=10.3)
發(fā)表時間:2024/6/17
作者:Chen Y, Ouyang D, Wang Y, et al.
作者單位:中山大學(xué)腫瘤中心
使用產(chǎn)品:Human CXCL10, CSF1, IL-10 and MMP-9 ELISA Kits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11184188/
14. Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice.(Journal of Neuroinflammation, IF=9.3)
發(fā)表時間:2024/7/25
作者:He Y, Zhao J, Ma Y, et al.
作者單位:上海市靜安區(qū)中心醫(yī)院
使用產(chǎn)品:Mouse IL-6 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/38849869/
15. Fabrication of chitosan-based emulsion as an adjuvant to enhance nasal mucosal immune responses.(International Journal of Biological Macromolecules, IF=7.7)
發(fā)表時間:2024/6/6
作者:Li D, Li W, Li S, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IFN-γ and IL-4 ELISA Kits
樣本類型:脾臟組織
https://pubmed.ncbi.nlm.nih.gov/38851606/
16. Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival.(Chinese Medical Journal, IF=7.5)
發(fā)表時間:2024/5/31
作者:Yuan W, Zhang H, Peng L, et al.
作者單位:中南大學(xué)湘雅第二醫(yī)院
使用產(chǎn)品:Mouse IFN-γ, IL-1β, IL-10 and IL-17 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38811343/
17. Artemisinin attenuated ischemic stroke induced pyroptosis by inhibiting ROS/TXNIP/NLRP3/Caspase-1 signaling pathway.(Biomedicine & Pharmacotherapy, IF=6.9)
發(fā)表時間:2024/6/14
作者:Wang Y, Yuan H, Shen D, et al.
作者單位:浙江中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-1β and IL-18 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38878634/
18. Chemopreventive effects of atractylenolide-III on mammary tumorigenesis via activation of the Nrf2/ARE pathway through autophagic degradation of Keap1.(Biomedicine & Pharmacotherapy, IF=6.9)
發(fā)表時間:2024/6/3
作者:Long F, Wang P, Ma Y, et al.
作者單位:成都醫(yī)學(xué)院
使用產(chǎn)品:Rat TNF-α, IL-6 and IL-1β ELISA Kits
樣本類型:乳腺組織
https://pubmed.ncbi.nlm.nih.gov/38834007/
19. DHTPY-Cu@ZOL-Enhanced Photodynamic Therapy: A Strategic Platform for Advanced Treatment of Drug-Resistant Bacterial Wound Infections.(International Journal of Nanomedicine, IF=6.6)
發(fā)表時間:2024/6/21
作者:Hou B, Li B, Deng W, et al.
作者單位:南方醫(yī)科大學(xué)第三附屬醫(yī)院
使用產(chǎn)品:Rat TGF-β1 and IL-6 ELISA Kits
樣本類型:組織樣本
https://pubmed.ncbi.nlm.nih.gov/38919773/
20. Nerve growth factor alleviates arsenic-induced testicular injury by enhancing the function of Sertoli cells.(Ecotoxicology and Environmental Safety, IF=6.2)
發(fā)表時間:2024/6/10
作者:Yang Y, Hong Y, Han J, et al.
作者單位:貴州醫(yī)科大學(xué)
使用產(chǎn)品:Goat Anti-Rabbit IgG secondary antibody
https://pubmed.ncbi.nlm.nih.gov/38861803/
21. Bifidobacterium adolescentis-derived hypaphorine alleviates acetaminophen hepatotoxicity by promoting hepatic Cry1 expression.(Journal of Translational Medicine, IF=6.1)
發(fā)表時間:2024/5/31
作者:Qin P, Li Y, Su Y, et al.
作者單位:廣東藥科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and MCP-1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38822329/
22. β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.(Chinese Medicine, IF=5.3)
發(fā)表時間:2024/6/15
作者:Zhao Q, Chen L, Zhang X, et al.
作者單位:中國藥科大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38879549/
23. Human amniotic epithelial stem cell-derived dopaminergic neuron-like cells ameliorate motor dysfunction in a rat model of Parkinson's disease.(Life Sciences, IF=5.2)
發(fā)表時間:2024/6/9
作者:Jiang T, Huang J, Xu B, et al.
作者單位:中國農(nóng)業(yè)大學(xué)
使用產(chǎn)品:IHC DAB
https://pubmed.ncbi.nlm.nih.gov/38843067/
24. Mycobacterium tuberculosis FadD18 Promotes Proinflammatory Cytokine Secretion to Inhibit the Intracellular Survival of Bacillus Calmette–Guérin.(Cells, IF=5.1)
發(fā)表時間:2024/6/11
作者:Peng Y, Tang T, Li Q, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Human TNF-α, IL-6 and IL-1β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38920649/
25. Impact of Hypoxia-Inducible Factor-1α on Host Immune Metabolism and Tissue Damage During Mycobacterium bovis Infection.(The Journal of Infectious Diseases, IF=5)
發(fā)表時間:2024/6/6
作者:Nan Y, Wang Y, Dong Y, et al.
作者單位:中國農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, IL-10, IL-17 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38843067/
26. Peripheral cytokine interleukin-10 alleviates perihematomal edema after intracerebral hemorrhage via interleukin-10 receptor/JAK1/STAT3 signaling.(CNS Neuroscience & Therapeutics, IF=4.8)
發(fā)表時間:2024/6/12
作者:Xu Y, Wang K, Dai Y, et al.
作者單位:陸軍軍醫(yī)大學(xué)
使用產(chǎn)品:Mouse IL-10 ELISA Kit
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38867395/
27. Identification of Effective Components in Flos Chrysanthemi Indici for Alleviating Gouty Inflammation through Integrated Absorption and Metabolism Studies.(Food Bioscience, IF=4.8)
發(fā)表時間:2024/6/20
作者:Huang Y, Xu T, Yuan Y, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Human IL-1β, IL-18, IL-6 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S2212429224010460
28. Taraxasterol protects against acetaminophen-induced hepatotoxicity by reducing liver inflammatory response and ameliorating oxidative stress in mice.(International Immunopharmacology, IF=4.8)
發(fā)表時間:2024/6/28
作者:Lin W, Gu B, Gu Y, et al.
作者單位:南通大學(xué)
使用產(chǎn)品:Mouse IL-1β, TNF-α, IL-6 and MCP-1 ELISA Kits
樣本類型:肝臟組織
https://pubmed.ncbi.nlm.nih.gov/38943970/
29. The antiangiogenic effect of total saponins of Panax japonicus C.A. Meyer in rheumatoid arthritis is mediated by targeting the HIF-1α/VEGF/ANG-1 axis.(Journal of Ethnopharmacology, IF=4.8)
發(fā)表時間:2024/6/3
作者:Guo X, Zhang J, Feng Z, et al.
作者單位:廣州中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse HIF-1α, VEGF-A and ANG-1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38838922/
30. Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway.(Molecular Neurobiology, IF=4.6)
發(fā)表時間:2024/6/18
作者:Ge Y, Dou X, Chen P, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院
使用產(chǎn)品:Mouse IL-1β, IL-10 and IL-4 ELISA Kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38886327/
31. Role of transforming growth factor-β1 pathway in angiogenesis induced by chronic stress in colorectal cancer.(Cancer Biology & Therapy, IF=4.4)
發(fā)表時間:2024/6/10
作者:Zhang J, Deng Y T, Liu J, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Human TGF-β1 ELISA kit; Mouse TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38857055/
32. Antioxidant, Antimicrobial, and Anti-Inflammatory Effects of Liriodendron chinense Leaves.(ACS Omega, IF=3.7)
發(fā)表時間:2024/6/10
作者:Wang Y L, Ni Q, Zeng W H, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits
樣本類型:肺組織
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11209703/
33. Enhanced anti-tumor activity mediated by combination chimeric antigen receptor T cells targeting GD2 and GPC2 in high-risk neuroblastoma.(Cytotherapy, IF=3.7)
發(fā)表時間:2024/5/31
作者:Wu H, Zhang G, Liu Z, et al.
作者單位:首都醫(yī)科大學(xué)宣武醫(yī)院
使用產(chǎn)品:Mouse IFN-γ, IL-2, TNF-α, IL-15, TGF-β1and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38904586/
34. DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis.(Neurochemical Research, IF=3.7)
發(fā)表時間:2024/6/4
作者:Cui Y, Hu Z, Wang L, et al.
作者單位:中南大學(xué)
使用產(chǎn)品:Rat TNF-α, IL-1β and IL-6 ELISA Kits
樣本類型:海馬組織
https://pubmed.ncbi.nlm.nih.gov/38834844/
35. CCL22 Induces the Polarization of Immature Dendritic Cells into Tolerogenic Dendritic Cells in Radiation-Induced Lung Injury through the CCR4–Dectin2–PLC-γ2–NFATC2–Nr4a2–PD-L1 Signaling Pathway.(The Journal of Immunology, IF=3.6)
發(fā)表時間:2024/6/10
作者:Liu B, Wang Y, Ma L, et al.
作者單位:北京放射醫(yī)學(xué)研究所
使用產(chǎn)品:Mouse CCL22, IFN-γ, IL-1β, IL-12p70, IL-6 and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38856585/
36. Specific immunological characteristics and risk factor of XBB variants re-infection in nasopharyngeal carcinoma patients after BA.5 infection.(Virology, IF=2.8)
發(fā)表時間:2024/6/28
作者:Lei Y, Xu N, Niu C, et al.
作者單位:廣州醫(yī)科大學(xué)附屬第二醫(yī)院
使用產(chǎn)品:TMB (standard sensitivity)
https://www.sciencedirect.com/science/article/abs/pii/S0042682224001636
37. Aspirin and Celecoxib Regulate Notch1/Hes1 Pathway to Prevent Pressure Overload-Induced Myocardial Hypertrophy.(International Heart Journal, IF=1.2)
發(fā)表時間:2024/5/31
作者:Wei M, Lu Z, Zhang H, et al.
作者單位:內(nèi)蒙古醫(yī)科大學(xué)
使用產(chǎn)品:Rat IL-6, IL-1β, TNF-α and IL-10 ELISA Kits
樣本類型:心臟組織
https://pubmed.ncbi.nlm.nih.gov/38825493/