有臨床證據(jù)表面懷孕期間發(fā)生的生理和免疫變化與感染和敗血癥期間疾病惡化的結(jié)果有關(guān),但這些關(guān)聯(lián)是如何加劇炎癥的發(fā)展還沒有被研究過。最近,南方醫(yī)科大學(xué)的研究團(tuán)隊在期刊《Immunity》(IF=43.474)上發(fā)表題為 “ Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation. ” 的文章,該研究使用抗生素治療和糞便微生物轉(zhuǎn)移,證明膿毒癥易感性是由妊娠誘導(dǎo)的小鼠和人類腸道微生物組的變化驅(qū)動的。綜合多組學(xué)和基因工程細(xì)菌揭示,懷孕期間Parabacteroides merdae (P. merdae)(副擬桿菌科(擬桿菌科))數(shù)量減少導(dǎo)致芒柄花素(Formononetin,F(xiàn)MN)減少和巨噬細(xì)胞死亡增加。從機(jī)制上證明,F(xiàn)MN通過抑制hnRNPUL2的核積累和隨后與NLRP3啟動子的結(jié)合來抑制巨噬細(xì)胞的核下垂。用FMN治療或敲除鼠hnRNPUL2可預(yù)防膿毒性炎癥。P. merdae和FMN的腸道豐度與膿毒癥患者的進(jìn)展呈負(fù)相關(guān)。該篇文章研究成果揭示了微生物免疫軸在妊娠膿毒癥宿主中被破壞,突出了FMN-hnRNPUL2-NLRP3軸在為膿毒癥的治療提供有前景的策略和潛力。
本文中使用了欣博盛Mouse IL-18, IL-1β和 IL-6 ELISA kits檢測了血清樣本中這些細(xì)胞因子的含量。
1.文章題目:Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation.
期 刊:Immunity(影響因子:43.474)
發(fā)表時間:14 February 2023
作 者:Chen X, Wu R, Li L, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-18, IL-1β and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36792573/
2.文章題目:Amyloid-β/Tau burden and neuroinflammation dual-targeted nanomedicines synergistically restore memory and recognition of Alzheimer’s disease mice.
期 刊:Nano Today(影響因子:18.962)
發(fā)表時間:20 February 2023
作 者:Zhang L, Hou S, Movahedi F, et al.
作者單位:中國科學(xué)院過程工程研究所
使用產(chǎn)品:Mouse IL-6, IL-18 and TNF-α ELISA kits
樣本類型:腦組織
https://www.sciencedirect.com/science/article/pii/S1748013223000373
3.文章題目:Quantitative Comparison of Gold Nanoparticle Delivery via the Enhanced Permeation and Retention (EPR) Effect and Mesenchymal Stem Cell (MSC)-Based Targeting.
期 刊: ACS nano(影響因子:18.027)
發(fā)表時間:1 February 2023
作 者:Xu L, Xu M, Sun X, et al.
作者單位:中國科學(xué)院生態(tài)環(huán)境科學(xué)研究中心
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36717361/
4.文章題目:A hierarchical tumor-targeting strategy for eliciting potent antitumor immunity against triple negative breast cancer.
期 刊:Biomaterials(影響因子:15.304)
發(fā)表時間:21 February 2023
作 者:Lin M, Cai Y, Chen G, et al.
作者單位:中山大學(xué)
使用產(chǎn)品:Mouse PD-L1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36854221/
5.文章題目:Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells.
期 刊:Acta Pharmaceutica Sinica B(影響因子:14.903)
發(fā)表時間:8 February 2023
作 者:Sun X, Xu X, Wang J, et al.
作者單位:吉林大學(xué)
使用產(chǎn)品:Mouse IL-15 ELISA kit
https://www.sciencedirect.com/science/article/pii/S2211383523000291
6.文章題目:Immune surveillance of brain metastatic cancer cells is mediated by IFITM1.
期 刊:The EMBO Journal(影響因子:14.012)
發(fā)表時間:17 February 2023
作 者:She X, Shen S, Chen G, et al.
作者單位:同濟(jì)大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA kit
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/36799040/
7.文章題目:Activation of Kruppel-like factor 6 by multi-walled carbon nanotubes in a diameter-dependent manner in THP-1 macrophages in vitro and bronchoalveolar lavage cells in vivo.
期 刊:Environmental Science: Nano(影響因子:9.473)
發(fā)表時間:1 February 2023
作 者:Song F, Tang X, Zhao W, et al.
作者單位:南華大學(xué)
使用產(chǎn)品:Human MCP-1 ELISA kit
https://pubs.rsc.org/en/content/articlelanding/2023/en/d2en00926a/unauth
8.文章題目:CRISPR/Cas12a coupling with RPA and MNPs for rapid and visualized identification of Methicillin-resistant Staphylococcus aureus.
期 刊:Sensors and Actuators B: Chemical(影響因子:9.221)
發(fā)表時間:20 February 2023
作 者:Wu X, Jin D, Ni W, et al.
作者單位:湖北中醫(yī)藥大學(xué)
使用產(chǎn)品:TMB底物
https://www.sciencedirect.com/science/article/abs/pii/S0925400523002617
9.文章題目:Immunogenicity Assessment for Swim bladder derived biomaterials.
期 刊:Biomaterials Science(影響因子:7.59)
發(fā)表時間:2 February 2023
作 者:Kong Y, Liu J, Jiang H, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院和中國協(xié)和醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IgG and IgM ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36807688/
10.文章題目:Dietary Antioxidants Constructed Nanodrug for Immunotherapy of Metastatic Tumors.
期 刊:Journal of Materials Chemistry B(影響因子:7.571)
發(fā)表時間:27 February 2023
作 者:Wu X, Tan Y, Zhang J, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-10 ELISA kits
樣本類型:腫瘤組織勻漿
https://pubs.rsc.org/en/content/articlelanding/2023/tb/d2tb02773a/unauth
11.文章題目:Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy.
期 刊:Drug Delivery(影響因子:6.819)
發(fā)表時間:27 February 2023
作 者:Gao Y, Zhang Y, Xia H, et al.
作者單位:沈陽藥科大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://www.tandfonline.com/doi/full/10.1080/10717544.2023.2183814
12.文章題目:Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration.
期 刊:Communications Biology(影響因子:6.548)
發(fā)表時間:20 February 2023
作 者:Yu H, Wang Y, Gao J, et al.
作者單位:廈門大學(xué)
使用產(chǎn)品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36804475/
13.文章題目:Nanoparticle vaccine based on the envelope protein domain III of Japanese encephalitis virus elicits robust protective immune responses in mice.
期 刊:Nanomedicine(影響因子:6.096)
發(fā)表時間:15 February 2023
作 者:Yao M, Ren X, Yin M, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-4 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36789970/
14.文章題目:Integrated Proteomics and Metabolomics Analysis to Explore the Amelioration Mechanisms of Rosa roxburghii Tratt Fruit Polyphenols on Lipopolysaccharide-Induced Acute Lung Injury Mice.
期 刊:Journal of Agricultural and Food Chemistry(影響因子:5.895)
發(fā)表時間:6 February 2023
作 者:Tang L, Zhang S, Zhang M, et al.
作者單位:貴州醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, IL-10 and TNF-α ELISA kits
樣本類型:肺組織
https://pubmed.ncbi.nlm.nih.gov/36745194/
15.文章題目:Anthocyanins from Lycium ruthenicum Murray Ameliorated High-Fructose Diet-Induced Neuroinflammation through the Promotion of the Integrity of the Intestinal Barrier and the Proliferation of Lactobacillus.
期 刊:Journal of Agricultural and Food Chemistry(影響因子:5.895)
發(fā)表時間:1 February 2023
作 者:Peng Y, Dong W, Chen G, et al.
作者單位:南京農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-10 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36725206/
16.文章題目:Optimal timing of free total rhubarb anthraquinones on immune regulation in rats with severe acute pancreatitis.
期 刊:Journal of Ethnopharmacology(影響因子:5.195)
發(fā)表時間:15 February 2023
作 者:Huang L, Zeng Y, Duan L, et al.
作者單位:西南醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-8 ELISA kit
樣本類型:小腸組織
https://pubmed.ncbi.nlm.nih.gov/36806482/
17.文章題目:Protective effect and underlying mechanism of muscone on acute cerebral ischemia-reperfusion injury in rats.
期 刊:Journal of Ethnopharmacology(影響因子:5.195)
發(fā)表時間:24 February 2023
作 者:Zhang P, You S, Ding X, et al.
作者單位:上海中醫(yī)藥大學(xué)
使用產(chǎn)品:Human VEGF, MMP-9 and bFGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36841376/
18.文章題目:VX-765 ameliorates CKD VSMC calcification by regulating STAT3 activation.
期 刊:European Journal of Pharmacology(影響因子:5.195)
發(fā)表時間:28 February 2023
作 者:Duan Y, Peng Z, Zhong S, et al.
作者單位:南華大學(xué)
使用產(chǎn)品:Rat IL-1β, IL-18, and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36858340/
19.文章題目:Osteoprotegerin deficiency aggravates methionine–choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
期 刊:Scientific Reports(影響因子:4.996)
發(fā)表時間:23 February 2023
作 者:Wu S, Wu Y, Lin L, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Histostain-Plus IHC Kit, Mouse Primary
https://pubmed.ncbi.nlm.nih.gov/36823220/
20.文章題目:Production and Anti-Inflammatory Performance of PVA Hydrogels Loaded with Curcumin Encapsulated in Octenyl Succinic Anhydride Modified Schizophyllan as Wound Dressings.
期 刊:Molecules(影響因子:4.927)
發(fā)表時間:1 February 2023
作 者:Tu L, Fan Y, Deng Y, et al.
作者單位:廣西大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36770985/
21.文章題目:Evaluation of biomarkers from peritoneal fluid as predictors of severity for abdominal sepsis patients following emergency laparotomy.
期 刊:Journal of Inflammation Research(影響因子:4.631)
發(fā)表時間:23 February 2023
作 者:Zhao J, Zhang T, Deng Z, et al.
作者單位:天津醫(yī)科大學(xué)
使用產(chǎn)品:Human IL-3 ELISA kit
https://www.tandfonline.com/doi/full/10.2147/JIR.S401428
22.文章題目:Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages.
期 刊:Bone & Joint Research(影響因子:4.41)
發(fā)表時間:1 February 2023
作 者:Mo H, Wang Z, He Z, et al.
作者單位:華中科技大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36718653/
23.文章題目:Dual-responsive antibiotic and baicalein co-delivery nanoparticles with enhanced synergistic antibacterial activity.
期 刊:Journal of Biomaterials Science Polymer Edition(影響因子:3.682)
發(fā)表時間:17 February 2023
作 者:Liu Y, Qian J, Zhao X, et al..
作者單位:貴州醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://www.tandfonline.com/doi/abs/10.1080/09205063.2023.2182575
24.文章題目:Isochlorogenic Acid C Restrains Erk/JNK/NF-κB Signaling to Alleviate Inflammatory Response and Promote Cell Apoptosis.
期 刊:Journal of Food Biochemistry(影響因子:3.654)
發(fā)表時間:20 February 2023
作 者:Liu Y, Liang J, Ding Q, et al.
作者單位:貴州中醫(yī)藥大學(xué)
使用產(chǎn)品:Rat IL-1β, IL-6, TNF-α, IFN-γ,CXCL1, IL-17/IL-17A ELISA kits, Human IL-1β , IL-18,MIP-1α, MCP-1 ELISA kits
https://www.hindawi.com/journals/jfbc/2023/5547108/
25.文章題目:Resveratrol Inhibits Activation of Microglia after Stroke through Triggering Translocation of Smo to Primary Cilia.
期 刊:Journal of Personalized Medicine(影響因子:3.508)
發(fā)表時間:1 February 2023
作 者:Liao H, Huang J, Liu J, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β and IL-10 ELISA kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/36836502/
26.文章題目:Anti-TNFR2 enhanced the antitumor activity of a new HMGN1/3M-052 stimulated dendritic cell vaccine in a mouse model of colon cancer.
期 刊:Biochemical and Biophysical Research Communications(影響因子:3.322)
發(fā)表時間:16 February 2023
作 者:Zhu L, Zhang X, Chen X, et al.
作者單位:貴州大學(xué)醫(yī)學(xué)院
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36868074/
27.文章題目:Filamin A is overexpressed in non-alcoholic steatohepatitis and contributes to the progression of inflammation and fibrosis.
期 刊:Biochemical and Biophysical Research Communications(影響因子:3.322)
發(fā)表時間:22 February 2023
作 者:Lu Y, Wang M, Zhao M, et al.
作者單位:四川大學(xué)
使用產(chǎn)品:Human TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36863213/
28.文章題目:Irisin Attenuates Fine Particulate Matter Induced Acute Lung Injury by Regulating Nod2/NF-κB Signaling Pathway.
期 刊:Immunobiology(影響因子:3.152)
發(fā)表時間:24 February 2023
作 者:Jiao R, Han Z, Ma J, et al.
作者單位:河北醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β and IL-18 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0171298523000268
29.文章題目:A multi-target protective effect of Danggui-Shaoyao-San on the vascular endothelium of atherosclerotic mice.
期 刊:BMC Complementary Medicine and Therapies(影響因子:2.838)
發(fā)表時間:20 February 2023
作 者:Sun Y, Gao Y, Zhou L, et al.
作者單位:北京中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-8 ELISA kit
樣本類型:主動脈組織
https://pubmed.ncbi.nlm.nih.gov/36803348/
30.文章題目:Roles of PADI4 in the expression of cytokines involved in inflammation and adhesion in differentiated NB4 cells treated with ATRA.
期 刊:Experimental and Therapeutic Medicine(影響因子:2.751)
發(fā)表時間:1 February 2023
作 者:Sun X, Mu X, Li F, et al.
作者單位:山東大學(xué)
使用產(chǎn)品:Human TNF-α, IL-1β and IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36815967/
31.文章題目:Anti‐Inflammatory Activities of Monoterpene and Sesquiterpene Glycosides from the Aqueous Extract of Artemisia annua L.
期 刊:Chemistry & Biodiversity(影響因子:2.745)
發(fā)表時間:5 February 2023
作 者:Wu Q G, Huang L Y, Fan M H, et al.
作者單位:上海中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36740572/
32.文章題目:Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway.
期 刊:Molecular Biology Reports(影響因子:2.742)
發(fā)表時間:1 February 2023
作 者:Liao H, Huang J, Liu J, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36725745/
33.文章題目:Sitagliptin Attenuates Porphyromonas Gingivalis Virulence and Inflammatory Response in Macrophage on Titanium.
期 刊:Archives of Oral Biology(影響因子:2.64)
發(fā)表時間:23 February 2023
作 者:Tang W, Du M, Zhang S, et al.
作者單位:武漢大學(xué)口腔醫(yī)院
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36871330/
34.文章題目:Effect of lipoxin A 4 methyl ester from arachidonic acid on JAK2/STAT3 pathway after cerebral ischemia-reperfusion injury.
期 刊:Food Science and Technology(影響因子:2.602)
發(fā)表時間:1 February 2023
作 者:YE X, WU Y, CHEN Q, et al.
作者單位:湖北文理學(xué)院附屬醫(yī)院
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://www.scielo.br/j/cta/a/F6mqLNJSNCbFnHRnxxBW8tw/abstract/?lang=en
35.文章題目:The effects of alginate lyase treatment on structural characteristics and anti‐photoaging activity of alginate from Sargassum fusiforme.
期 刊:Food Frontiers(影響因子:2.05)
發(fā)表時間:24 February 2023
作 者:Chang S, Hu J, Zhu B, et al.
作者單位:華南理工大學(xué)
使用產(chǎn)品:Human MMP-1 and MMP-9 ELISA kits
https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.218
36.文章題目:Probiotics-loaded carrageenan microspheres for inflammatory bowel disease treatment.
期 刊:Materials Research Express(影響因子:2.025)
發(fā)表時間:17 February 2023
作 者:Yang X, Li C, Wu Q, et al.
作者單位:九江市第一人民醫(yī)院
使用產(chǎn)品:Mouse IL-10, IL-6, IL-β, TNF-α ELISA kits
https://iopscience.iop.org/article/10.1088/2053-1591/acbae6/meta
37.文章題目:The inhibitory function of GDF11/BMP11 in liver cancer by inducing apoptosis and ROS–JNK pathway.
期 刊:Oncologie(影響因子:0.9)
發(fā)表時間:15 February 2023
作 者:Zhang Y, Wang C, Li J, et al.
作者單位:三峽醫(yī)學(xué)院附屬人民醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://www.degruyter.com/document/doi/10.1515/oncologie-2023-0001/html